DegronMD

Uniprot ID: Q9GZZ8

Source protein: Extracellular glycoprotein lacritin

Source gene: LACRT

Class: DEG_APCC_DBOX_1

Location: 77:85

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6312

ASA_SCORE: 83.8667

COIL: 0.6152

CONS_SCORE: 1

DSS_SCORE: 0.4035

HELIX: 0.3422

FCONS_SCORE: 1.0121

RIG_SCORE: 0.7597

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N82S	TCGA-CN-A63Y	HNSC	TCGA	SRQELNPLK	DEG_APCC_DBOX_1	0.5958
p.N82S	DO44422	HNSC	ICGC	SRQELNPLK	DEG_APCC_DBOX_1	0.5958
p.E89K	TCGA-D3-A2JN	SKCM	TCGA	SRQELNPLK	DEG_APCC_DBOX_1	0.2222
p.E89K	DO47590	SKCM	ICGC	SRQELNPLK	DEG_APCC_DBOX_1	0.2222
p.L84M	TCGA-EE-A2MM	SKCM	TCGA	SRQELNPLK	DEG_APCC_DBOX_1	0.5999
p.L84M	DO37770	SKCM	ICGC	SRQELNPLK	DEG_APCC_DBOX_1	0.5999
p.E89D	TCGA-OR-A5JA	ACC	TCGA	SRQELNPLK	DEG_APCC_DBOX_1	0.2222
p.E89Q	TCGA-UF-A7JS	HNSC	TCGA	SRQELNPLK	DEG_APCC_DBOX_1	0.2222
p.E89Q	DO52119	HNSC	ICGC	SRQELNPLK	DEG_APCC_DBOX_1	0.2222
p.A72T	DO233638	GACA	ICGC	SRQELNPLK	DEG_APCC_DBOX_1	0.1944
p.L84Q	DO228299	LICA	ICGC	SRQELNPLK	DEG_APCC_DBOX_1	0.7765
p.V88M	SIDM00473	Oral Cavity Carcinoma	GDSC	SRQELNPLK	DEG_APCC_DBOX_1	0.25
p.V88M	ACH-000619	Head and Neck Cancer	CCLE	SRQELNPLK	DEG_APCC_DBOX_1	0.25
p.V88M	PE/CA-PJ15	upper_aerodigestive_tract	COSMIC	SRQELNPLK	DEG_APCC_DBOX_1	0.25
p.S86T	SIDM00878	Breast Carcinoma	GDSC	SRQELNPLK	DEG_APCC_DBOX_1	0.3056
p.S86T	ACH-000930	Breast Cancer	CCLE	SRQELNPLK	DEG_APCC_DBOX_1	0.3056
p.S86T	HCC1569	breast	COSMIC	SRQELNPLK	DEG_APCC_DBOX_1	0.3056
p.A87V	KM12	large_intestine	COSMIC	SRQELNPLK	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9GZZ8	Extracellular glycoprotein lacritin	DEG_APCC_DBOX_1	77:85	SRQELNPLK	APC,CDC20,FZR1	0.6312	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons