DegronMD - Q9H013(ADAM19)

ADAM19

UniProt ID: Q9H013

Entrez ID: 8728

Protein name: Disintegrin and metalloproteinase domain-containing protein 19 (ADAM 19) (EC 3.4.24.-) (Meltrin-beta) (Metalloprotease and disintegrin dendritic antigen marker) (MADDAM)

External links: UniprotKB HGNC RefSeq COSMIC

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GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G911E	TCGA-78-7220	LUAD	TCGA	LAPKVSPREALKV	DEG_ODPH_VHL_1	898:910	Mutation rewiring degron network	0.3056
p.M913V	TCGA-A5-A1OH	UCEC	TCGA	LAPKVSPREALKV	DEG_ODPH_VHL_1	898:910	Mutation rewiring degron network	0.25
p.M913I	TCGA-A7-A4SD	BRCA	TCGA	LAPKVSPREALKV	DEG_ODPH_VHL_1	898:910	Mutation rewiring degron network	0.25
p.I914T	TCGA-AJ-A3EL	UCEC	TCGA	LAPKVSPREALKV	DEG_ODPH_VHL_1	898:910	Mutation rewiring degron network	0.2222
p.I918L	TCGA-BR-A4PD	STAD	TCGA	LAPKVSPREALKV	DEG_ODPH_VHL_1	898:910	Mutation rewiring degron network	0.1111
p.A899T	TCGA-D1-A103	UCEC	TCGA	LAPKVSPREALKV	DEG_ODPH_VHL_1	898:910	Mutation altering degron motif	0.7139
p.A899T	DO42312	UCEC	ICGC	LAPKVSPREALKV	DEG_ODPH_VHL_1	898:910	Mutation altering degron motif	0.7139
p.P903S	TCGA-EB-A6R0	SKCM	TCGA	LAPKVSPREALKV	DEG_ODPH_VHL_1	898:910	Mutation altering degron motif	0.6752
p.P894L	TCGA-EE-A2GC	SKCM	TCGA	LAPKVSPREALKV	DEG_ODPH_VHL_1	898:910	Mutation rewiring degron network	0.2222
p.P894L	DO37839	SKCM	ICGC	LAPKVSPREALKV	DEG_ODPH_VHL_1	898:910	Mutation rewiring degron network	0.2222
p.Q890H	TCGA-IB-7651	PAAD	TCGA	LAPKVSPREALKV	DEG_ODPH_VHL_1	898:910	Mutation rewiring degron network	0.1111
p.Q890H	DO46657	PAAD	ICGC	LAPKVSPREALKV	DEG_ODPH_VHL_1	898:910	Mutation rewiring degron network	0.1111
p.R905L	DO224746	BRCA	ICGC	LAPKVSPREALKV	DEG_ODPH_VHL_1	898:910	Mutation altering degron motif	0.7316
p.R905L	DO52543	BRCA	ICGC	LAPKVSPREALKV	DEG_ODPH_VHL_1	898:910	Mutation altering degron motif	0.7316
p.M915I	DO2461	BRCA	ICGC	LAPKVSPREALKV	DEG_ODPH_VHL_1	898:910	Mutation rewiring degron network	0.1944
p.M915I	DO220886	MELA	ICGC	LAPKVSPREALKV	DEG_ODPH_VHL_1	898:910	Mutation rewiring degron network	0.1944
p.M915I	DO35188	PACA	ICGC	LAPKVSPREALKV	DEG_ODPH_VHL_1	898:910	Mutation rewiring degron network	0.1944
p.G913E	DO24409	LUAD	ICGC	LAPKVSPREALKV	DEG_ODPH_VHL_1	898:910	Mutation rewiring degron network	0.25
p.S918W	DO220859	MELA	ICGC	LAPKVSPREALKV	DEG_ODPH_VHL_1	898:910	Mutation rewiring degron network	0.1111
p.S909L	DO222843	MELA	ICGC	LAPKVSPREALKV	DEG_ODPH_VHL_1	898:910	Mutation altering degron motif	0.7667
p.S892F	DO37782	SKCM	ICGC	LAPKVSPREALKV	DEG_ODPH_VHL_1	898:910	Mutation blocking phosphorylation signal	0.6111
p.P905S	DO48646	SKCM	ICGC	LAPKVSPREALKV	DEG_ODPH_VHL_1	898:910	Mutation altering degron motif	0.6752
p.I920L	DO47831	STAD	ICGC	LAPKVSPREALKV	DEG_ODPH_VHL_1	898:910	Mutation rewiring degron network	0.0556
p.M915V	DO48180	UCEC	ICGC	LAPKVSPREALKV	DEG_ODPH_VHL_1	898:910	Mutation rewiring degron network	0.1944
p.I916T	DO41542	UCEC	ICGC	LAPKVSPREALKV	DEG_ODPH_VHL_1	898:910	Mutation rewiring degron network	0.1667
p.P900L	SIDM00909	Melanoma	GDSC	LAPKVSPREALKV	DEG_ODPH_VHL_1	898:910	Mutation altering degron motif	0.7582
p.P900L	ACH-000644	Skin Cancer	CCLE	LAPKVSPREALKV	DEG_ODPH_VHL_1	898:910	Mutation altering degron motif	0.7582
p.P900L	COLO-829	skin	COSMIC	LAPKVSPREALKV	DEG_ODPH_VHL_1	898:910	Mutation altering degron motif	0.7582

Kaplan plot for ADAM19 in

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*NOTE: the Kaplan plots were collected from OncoLnc