DegronMD

Uniprot ID: Q9H013

Source protein: Disintegrin and metalloproteinase domain-containing protein 19

Source gene: ADAM19

Class: DEG_ODPH_VHL_1

Location: 898:910

E3 ligase: VHL

DEGRON score: 0.6164

ASA_SCORE: 91.3846

COIL: 0.8075

CONS_SCORE: 0.2534

DSS_SCORE: 0.5358

HELIX: 0.1775

FCONS_SCORE: 0.9406

RIG_SCORE: 0.7164

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G911E	TCGA-78-7220	LUAD	TCGA	LAPKVSPREALKV	DEG_ODPH_VHL_1	0.3056
p.M913V	TCGA-A5-A1OH	UCEC	TCGA	LAPKVSPREALKV	DEG_ODPH_VHL_1	0.25
p.M913I	TCGA-A7-A4SD	BRCA	TCGA	LAPKVSPREALKV	DEG_ODPH_VHL_1	0.25
p.I914T	TCGA-AJ-A3EL	UCEC	TCGA	LAPKVSPREALKV	DEG_ODPH_VHL_1	0.2222
p.I918L	TCGA-BR-A4PD	STAD	TCGA	LAPKVSPREALKV	DEG_ODPH_VHL_1	0.1111
p.A899T	TCGA-D1-A103	UCEC	TCGA	LAPKVSPREALKV	DEG_ODPH_VHL_1	0.7139
p.A899T	DO42312	UCEC	ICGC	LAPKVSPREALKV	DEG_ODPH_VHL_1	0.7139
p.P903S	TCGA-EB-A6R0	SKCM	TCGA	LAPKVSPREALKV	DEG_ODPH_VHL_1	0.6752
p.P894L	TCGA-EE-A2GC	SKCM	TCGA	LAPKVSPREALKV	DEG_ODPH_VHL_1	0.2222
p.P894L	DO37839	SKCM	ICGC	LAPKVSPREALKV	DEG_ODPH_VHL_1	0.2222
p.Q890H	TCGA-IB-7651	PAAD	TCGA	LAPKVSPREALKV	DEG_ODPH_VHL_1	0.1111
p.Q890H	DO46657	PAAD	ICGC	LAPKVSPREALKV	DEG_ODPH_VHL_1	0.1111
p.R905L	DO224746	BRCA	ICGC	LAPKVSPREALKV	DEG_ODPH_VHL_1	0.7316
p.R905L	DO52543	BRCA	ICGC	LAPKVSPREALKV	DEG_ODPH_VHL_1	0.7316
p.M915I	DO2461	BRCA	ICGC	LAPKVSPREALKV	DEG_ODPH_VHL_1	0.1944
p.M915I	DO220886	MELA	ICGC	LAPKVSPREALKV	DEG_ODPH_VHL_1	0.1944
p.M915I	DO35188	PACA	ICGC	LAPKVSPREALKV	DEG_ODPH_VHL_1	0.1944
p.G913E	DO24409	LUAD	ICGC	LAPKVSPREALKV	DEG_ODPH_VHL_1	0.25
p.S918W	DO220859	MELA	ICGC	LAPKVSPREALKV	DEG_ODPH_VHL_1	0.1111
p.S909L	DO222843	MELA	ICGC	LAPKVSPREALKV	DEG_ODPH_VHL_1	0.7667
p.S892F	DO37782	SKCM	ICGC	LAPKVSPREALKV	DEG_ODPH_VHL_1	0.6111
p.P905S	DO48646	SKCM	ICGC	LAPKVSPREALKV	DEG_ODPH_VHL_1	0.6752
p.I920L	DO47831	STAD	ICGC	LAPKVSPREALKV	DEG_ODPH_VHL_1	0.0556
p.M915V	DO48180	UCEC	ICGC	LAPKVSPREALKV	DEG_ODPH_VHL_1	0.1944
p.I916T	DO41542	UCEC	ICGC	LAPKVSPREALKV	DEG_ODPH_VHL_1	0.1667
p.P900L	SIDM00909	Melanoma	GDSC	LAPKVSPREALKV	DEG_ODPH_VHL_1	0.7582
p.P900L	ACH-000644	Skin Cancer	CCLE	LAPKVSPREALKV	DEG_ODPH_VHL_1	0.7582
p.P900L	COLO-829	skin	COSMIC	LAPKVSPREALKV	DEG_ODPH_VHL_1	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPKVSPREALKV

Degron related mutations and impact score

Drug responses associated with ADAM19 mutations

All proteins holding degron of LAPKVSPREALKV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H013	Disintegrin and metalloproteinase domain-containing protein 19	DEG_ODPH_VHL_1	898:910	LAPKVSPREALKV	VHL	0.6164	More...