DegronMD - Q9H093(NUAK2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S377Y	TCGA-AR-A0TX	BRCA	TCGA	RKEND	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.3056
p.S377Y	DO1663	BRCA	ICGC	RKEND	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.3056
p.R370H	TCGA-B5-A11H	UCEC	TCGA	RKEND	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.1111
p.R370H	DO52591	BOCA	ICGC	RKEND	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.1111
p.R370H	DO42825	UCEC	ICGC	RKEND	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.1111
p.S373L	TCGA-EE-A29D	SKCM	TCGA	RKEND	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.1944
p.S373L	DO38123	SKCM	ICGC	RKEND	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.1944
p.R370C	TCGA-EO-A22U	UCEC	TCGA	RKEND	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.1111
p.R370C	DO43755	UCEC	ICGC	RKEND	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.1111
p.A384T	TCGA-EO-A3AY	UCEC	TCGA	RKEND	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.2778
p.A384T	DO43202	UCEC	ICGC	RKEND	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.2778
p.A392T	TCGA-VS-A9UJ	CESC	TCGA	RKEND	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.0556
p.A392T	DO219735	CESC	ICGC	RKEND	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.0556
p.R370S	DO229022	LICA	ICGC	RKEND	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.1111
p.T391M	DO35083	PACA	ICGC	RKEND	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.0833
p.A374T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	RKEND	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.2222
p.A374T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	RKEND	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.2222
p.A374T	Jurkat	haematopoietic and lymphoid tissue	COSMIC	RKEND	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.2222
p.L368P	ACH-000423	Skin Cancer	CCLE	RKEND	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.0556
p.K379M	ACH-000718	Lung Cancer	CCLE	RKEND	DEG_APCC_KENBOX_2	378:382	Mutation altering degron motif	0.8062
p.Q371R	ACH-000988	Endometrial/Uterine Cancer	CCLE	RKEND	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.1389
p.H372Y	ACH-000994	Endometrial/Uterine Cancer	CCLE	RKEND	DEG_APCC_KENBOX_2	378:382	Mutation rewiring degron network	0.1667

Kaplan plot for NUAK2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NUAK2

UniProt ID: Q9H093

Entrez ID: 81788

Protein name: NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (Omphalocele kinase 2) (SNF1/AMP kinase-related kinase) (SNARK)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NUAK2 in