DegronMD

Uniprot ID: Q9H093

Source protein: NUAK family SNF1-like kinase 2

Source gene: NUAK2

Class: DEG_APCC_KENBOX_2

Location: 378:382

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8263

ASA_SCORE: 112.36

COIL: 0.49

CONS_SCORE: 0.5306

DSS_SCORE: 0.7181

HELIX: 0.4884

FCONS_SCORE: 1.1221

RIG_SCORE: 0.6205

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S377Y	TCGA-AR-A0TX	BRCA	TCGA	RKEND	DEG_APCC_KENBOX_2	0.3056
p.S377Y	DO1663	BRCA	ICGC	RKEND	DEG_APCC_KENBOX_2	0.3056
p.R370H	TCGA-B5-A11H	UCEC	TCGA	RKEND	DEG_APCC_KENBOX_2	0.1111
p.R370H	DO52591	BOCA	ICGC	RKEND	DEG_APCC_KENBOX_2	0.1111
p.R370H	DO42825	UCEC	ICGC	RKEND	DEG_APCC_KENBOX_2	0.1111
p.S373L	TCGA-EE-A29D	SKCM	TCGA	RKEND	DEG_APCC_KENBOX_2	0.1944
p.S373L	DO38123	SKCM	ICGC	RKEND	DEG_APCC_KENBOX_2	0.1944
p.R370C	TCGA-EO-A22U	UCEC	TCGA	RKEND	DEG_APCC_KENBOX_2	0.1111
p.R370C	DO43755	UCEC	ICGC	RKEND	DEG_APCC_KENBOX_2	0.1111
p.A384T	TCGA-EO-A3AY	UCEC	TCGA	RKEND	DEG_APCC_KENBOX_2	0.2778
p.A384T	DO43202	UCEC	ICGC	RKEND	DEG_APCC_KENBOX_2	0.2778
p.A392T	TCGA-VS-A9UJ	CESC	TCGA	RKEND	DEG_APCC_KENBOX_2	0.0556
p.A392T	DO219735	CESC	ICGC	RKEND	DEG_APCC_KENBOX_2	0.0556
p.R370S	DO229022	LICA	ICGC	RKEND	DEG_APCC_KENBOX_2	0.1111
p.T391M	DO35083	PACA	ICGC	RKEND	DEG_APCC_KENBOX_2	0.0833
p.A374T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	RKEND	DEG_APCC_KENBOX_2	0.2222
p.A374T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	RKEND	DEG_APCC_KENBOX_2	0.2222
p.A374T	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	RKEND	DEG_APCC_KENBOX_2	0.2222
p.L368P	ACH-000423	Skin Cancer	CCLE	RKEND	DEG_APCC_KENBOX_2	0.0556
p.K379M	ACH-000718	Lung Cancer	CCLE	RKEND	DEG_APCC_KENBOX_2	0.8062
p.Q371R	ACH-000988	Endometrial/Uterine Cancer	CCLE	RKEND	DEG_APCC_KENBOX_2	0.1389
p.H372Y	ACH-000994	Endometrial/Uterine Cancer	CCLE	RKEND	DEG_APCC_KENBOX_2	0.1667

Drug responses associated with NUAK2 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00271	UNCLASSIFIED\|stomach	p.L527V (No)	GDSC	WZ4003	18.394
SIDM00210	UNCLASSIFIED\|ovary	p.R291W (No)	GDSC	WZ4003	9.8254
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L442fs*38 (No)	GDSC	WZ4003	116.77
SIDM00896	DLBC\|B_cell_lymphoma	p.N287T (No)	GDSC	WZ4003	5.2201
SIDM01229	NB\|neuroblastoma	p.Q261H (No)	GDSC	WZ4003	101.36
SIDM00312	MM\|myeloma	p.E467K (No)	GDSC	WZ4003	4.8122
SIDM00003	SKCM\|melanoma	p.Y459H (No)	GDSC	WZ4003	10.07
SIDM00498	COREAD\|large_intestine	p.G500A (No)	GDSC	WZ4003	61.925
SIDM00194	COREAD\|large_intestine	p.G500A (No)	GDSC	WZ4003	172.15
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.T289I (No)	GDSC	WZ4003	116.77
SIDM01045	UCEC\|endometrium	p.P452L (No)	GDSC	WZ4003	93.478
SIDM00056	THCA\|thyroid	p.D575A (No)	GDSC	WZ4003	10.219
SIDM00333	UCEC\|endometrium	p.Q371R (Yes)	GDSC	WZ4003	49.331
SIDM00217	COREAD\|large_intestine	p.H300R (No)	GDSC	WZ4003	161.81
SIDM00217	COREAD\|large_intestine	p.T227A (No)	GDSC	WZ4003	161.81
SIDM00217	COREAD\|large_intestine	p.T208A (No)	GDSC	WZ4003	161.81
SIDM00640	MESO\|mesothelioma	p.R290H (No)	GDSC	WZ4003	305.33
SIDM00673	BRCA\|breast	p.R134W (No)	GDSC	WZ4003	68.003
SIDM01067	LUAD\|lung_NSCLC_adenocarcinoma	p.E143K (No)	GDSC	WZ4003	21.858
SIDM00789	COREAD\|large_intestine	p.P588H (No)	GDSC	WZ4003	4.3663
SIDM00583	PAAD\|pancreas	p.K408N (No)	GDSC	WZ4003	219.82
SIDM00217	COREAD\|large_intestine	p.L442fs*38 (No)	GDSC	WZ4003	161.81
SIDM00241	BRCA\|breast	p.F155L (No)	GDSC	WZ4003	65.809
SIDM00394	CESC\|cervix	p.K507R (No)	GDSC	WZ4003	214.94
SIDM00080	SKCM\|melanoma	p.P433S (No)	GDSC	WZ4003	8.4813
SIDM00046	LUAD\|lung_NSCLC_adenocarcinoma	p.R268W (No)	GDSC	WZ4003	21.22
SIDM00230	SCLC\|lung_small_cell_carcinoma	p.V163M (No)	GDSC	WZ4003	14.028
SIDM00103	MESO\|mesothelioma	p.E526K (No)	GDSC	WZ4003	80.856
SIDM00556	NB\|neuroblastoma	p.L34I (No)	GDSC	WZ4003	180.01

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RKEND

Degron related mutations and impact score

Drug responses associated with NUAK2 mutations

All proteins holding degron of RKEND

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H093	NUAK family SNF1-like kinase 2	DEG_APCC_KENBOX_2	378:382	RKEND	APC,CDC20,FZR1	0.8263	More...