DegronMD - Q9H0H0(INTS2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R358Q	TCGA-AA-A00N	COAD	TCGA	RRQLLLELM	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.0556
p.R358Q	TCGA-AN-A046	BRCA	TCGA	RRQLLLELM	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.0556
p.R358Q	TCGA-EO-A3AY	UCEC	TCGA	RRQLLLELM	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.0556
p.R358Q	DO1285	BRCA	ICGC	RRQLLLELM	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.0556
p.R358Q	DO9876	COAD	ICGC	RRQLLLELM	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.0556
p.R358Q	DO43202	UCEC	ICGC	RRQLLLELM	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.0556
p.L344I	TCGA-B0-5119	KIRC	TCGA	RRQLLLELM	DEG_APCC_DBOX_1	340:348	Mutation altering degron motif	0.7174
p.L344I	DO18721	KIRC	ICGC	RRQLLLELM	DEG_APCC_DBOX_1	340:348	Mutation altering degron motif	0.7174
p.L347S	DO218182	BRCA	ICGC	RRQLLLELM	DEG_APCC_DBOX_1	340:348	Mutation altering degron motif	0.7667
p.S332T	SIDM00748	Non-Small Cell Lung Carcinoma	GDSC	RRQLLLELM	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.1111
p.S332T	SIDM00732	Glioblastoma	GDSC	RRQLLLELM	DEG_APCC_DBOX_1	340:348	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons