DegronMD

Uniprot ID: Q9H0H0

Source protein: Integrator complex subunit 2

Source gene: INTS2

Class: DEG_APCC_DBOX_1

Location: 340:348

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7234

ASA_SCORE: 47.4

COIL: 0.025

CONS_SCORE: 0.4079

DSS_SCORE: 0.0941

HELIX: 0.9669

FCONS_SCORE: 1.2727

RIG_SCORE: 0.8975

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R358Q	TCGA-AA-A00N	COAD	TCGA	RRQLLLELM	DEG_APCC_DBOX_1	0.0556
p.R358Q	TCGA-AN-A046	BRCA	TCGA	RRQLLLELM	DEG_APCC_DBOX_1	0.0556
p.R358Q	TCGA-EO-A3AY	UCEC	TCGA	RRQLLLELM	DEG_APCC_DBOX_1	0.0556
p.R358Q	DO1285	BRCA	ICGC	RRQLLLELM	DEG_APCC_DBOX_1	0.0556
p.R358Q	DO9876	COAD	ICGC	RRQLLLELM	DEG_APCC_DBOX_1	0.0556
p.R358Q	DO43202	UCEC	ICGC	RRQLLLELM	DEG_APCC_DBOX_1	0.0556
p.L344I	TCGA-B0-5119	KIRC	TCGA	RRQLLLELM	DEG_APCC_DBOX_1	0.7174
p.L344I	DO18721	KIRC	ICGC	RRQLLLELM	DEG_APCC_DBOX_1	0.7174
p.L347S	DO218182	BRCA	ICGC	RRQLLLELM	DEG_APCC_DBOX_1	0.7667
p.S332T	SIDM00748	Non-Small Cell Lung Carcinoma	GDSC	RRQLLLELM	DEG_APCC_DBOX_1	0.1111
p.S332T	SIDM00732	Glioblastoma	GDSC	RRQLLLELM	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H0H0	Integrator complex subunit 2	DEG_APCC_DBOX_1	340:348	RRQLLLELM	APC,CDC20,FZR1	0.7234	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons