DegronMD - Q9H159(CDH19)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G164R	TCGA-77-8144	LUSC	TCGA	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation rewiring degron network	0.2222
p.G164R	DO229177	LMS	ICGC	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation rewiring degron network	0.2222
p.G164R	DO26949	LUSC	ICGC	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation rewiring degron network	0.2222
p.Q169K	TCGA-A5-A1OF	UCEC	TCGA	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation rewiring degron network	0.0833
p.Q169K	DO229037	LICA	ICGC	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation rewiring degron network	0.0833
p.Q169K	DO42568	UCEC	ICGC	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation rewiring degron network	0.0833
p.P152S	TCGA-AP-A059	UCEC	TCGA	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation altering degron motif	0.5641
p.P152S	DO41361	UCEC	ICGC	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation altering degron motif	0.5641
p.E159D	TCGA-AX-A05Z	UCEC	TCGA	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation altering degron motif	0.5647
p.E159D	TCGA-EO-A22U	UCEC	TCGA	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation altering degron motif	0.5647
p.E159D	DO40884	UCEC	ICGC	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation altering degron motif	0.5647
p.E159D	DO43755	UCEC	ICGC	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation altering degron motif	0.5647
p.E159D	SIDM00534	Colorectal Carcinoma	GDSC	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation altering degron motif	0.5647
p.E159D	ACH-000986	Colon/Colorectal Cancer	CCLE	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation altering degron motif	0.5647
p.E159D	HT-115	large intestine	COSMIC	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation altering degron motif	0.5647
p.P152L	TCGA-B5-A3FC	UCEC	TCGA	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation altering degron motif	0.6471
p.P152L	DO41871	UCEC	ICGC	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation altering degron motif	0.6471
p.A155T	TCGA-EA-A410	CESC	TCGA	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation altering degron motif	0.6028
p.A155T	DO49929	CESC	ICGC	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation altering degron motif	0.6028
p.M160I	DO222755	COCA	ICGC	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation altering degron motif	0.6507
p.E151G	DO233235	GACA	ICGC	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation altering degron motif	0.7199
p.P152T	DO228974	LICA	ICGC	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation altering degron motif	0.5919
p.A155D	DO229034	LICA	ICGC	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation altering degron motif	0.6682
p.V167I	DO46333	OV	ICGC	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation rewiring degron network	0.1389
p.V167I	SIDM01652	Non-Cancerous	GDSC	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation rewiring degron network	0.1389
p.V167I	ACH-002352	Non-Cancerous	CCLE	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation rewiring degron network	0.1389
p.A155S	SIDM00466	Ovarian Carcinoma	GDSC	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation altering degron motif	0.6477
p.A155S	SIDM00585	Hepatocellular Carcinoma	GDSC	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation altering degron motif	0.6477
p.A155S	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation altering degron motif	0.6477
p.A155S	SIDM00469	Pancreatic Carcinoma	GDSC	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation altering degron motif	0.6477
p.A155S	ACH-000320	Pancreatic Cancer	CCLE	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation altering degron motif	0.6477
p.A155S	ACH-000443	Ovarian Cancer	CCLE	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation altering degron motif	0.6477
p.A155S	ACH-000480	Liver Cancer	CCLE	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation altering degron motif	0.6477
p.A155S	ACH-000917	Esophageal Cancer	CCLE	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation altering degron motif	0.6477
p.A155S	ACH-001060	Lymphoma	CCLE	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation altering degron motif	0.6477
p.T165A	SIDM00217	Colorectal Carcinoma	GDSC	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation rewiring degron network	0.1944
p.T165A	ACH-000999	Colon/Colorectal Cancer	CCLE	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation rewiring degron network	0.1944
p.T165A	SNU-1040	large intestine	COSMIC	DEPYEAIVPEM	DEG_COP1_1	150:160	Mutation rewiring degron network	0.1944

Kaplan plot for CDH19 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDH19

UniProt ID: Q9H159

Entrez ID: 28513

Protein name: Cadherin-19

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDH19 in