DegronMD

Uniprot ID: Q9H159

Source protein: Cadherin-19

Source gene: CDH19

Class: DEG_COP1_1

Location: 150:160

E3 ligase: COP1

DEGRON score: 0.8019

ASA_SCORE: 52.9727

COIL: 0.3954

CONS_SCORE: 0.887

DSS_SCORE: 0.5212

HELIX: 0.0141

FCONS_SCORE: 1.0932

RIG_SCORE: 0.7944

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G164R	TCGA-77-8144	LUSC	TCGA	DEPYEAIVPEM	DEG_COP1_1	0.2222
p.G164R	DO229177	LMS	ICGC	DEPYEAIVPEM	DEG_COP1_1	0.2222
p.G164R	DO26949	LUSC	ICGC	DEPYEAIVPEM	DEG_COP1_1	0.2222
p.Q169K	TCGA-A5-A1OF	UCEC	TCGA	DEPYEAIVPEM	DEG_COP1_1	0.0833
p.Q169K	DO229037	LICA	ICGC	DEPYEAIVPEM	DEG_COP1_1	0.0833
p.Q169K	DO42568	UCEC	ICGC	DEPYEAIVPEM	DEG_COP1_1	0.0833
p.P152S	TCGA-AP-A059	UCEC	TCGA	DEPYEAIVPEM	DEG_COP1_1	0.5641
p.P152S	DO41361	UCEC	ICGC	DEPYEAIVPEM	DEG_COP1_1	0.5641
p.E159D	TCGA-AX-A05Z	UCEC	TCGA	DEPYEAIVPEM	DEG_COP1_1	0.5647
p.E159D	TCGA-EO-A22U	UCEC	TCGA	DEPYEAIVPEM	DEG_COP1_1	0.5647
p.E159D	DO40884	UCEC	ICGC	DEPYEAIVPEM	DEG_COP1_1	0.5647
p.E159D	DO43755	UCEC	ICGC	DEPYEAIVPEM	DEG_COP1_1	0.5647
p.E159D	SIDM00534	Colorectal Carcinoma	GDSC	DEPYEAIVPEM	DEG_COP1_1	0.5647
p.E159D	ACH-000986	Colon/Colorectal Cancer	CCLE	DEPYEAIVPEM	DEG_COP1_1	0.5647
p.E159D	HT-115	large_intestine	COSMIC	DEPYEAIVPEM	DEG_COP1_1	0.5647
p.P152L	TCGA-B5-A3FC	UCEC	TCGA	DEPYEAIVPEM	DEG_COP1_1	0.6471
p.P152L	DO41871	UCEC	ICGC	DEPYEAIVPEM	DEG_COP1_1	0.6471
p.A155T	TCGA-EA-A410	CESC	TCGA	DEPYEAIVPEM	DEG_COP1_1	0.6028
p.A155T	DO49929	CESC	ICGC	DEPYEAIVPEM	DEG_COP1_1	0.6028
p.M160I	DO222755	COCA	ICGC	DEPYEAIVPEM	DEG_COP1_1	0.6507
p.E151G	DO233235	GACA	ICGC	DEPYEAIVPEM	DEG_COP1_1	0.7199
p.P152T	DO228974	LICA	ICGC	DEPYEAIVPEM	DEG_COP1_1	0.5919
p.A155D	DO229034	LICA	ICGC	DEPYEAIVPEM	DEG_COP1_1	0.6682
p.V167I	DO46333	OV	ICGC	DEPYEAIVPEM	DEG_COP1_1	0.1389
p.V167I	SIDM01652	Non-Cancerous	GDSC	DEPYEAIVPEM	DEG_COP1_1	0.1389
p.V167I	ACH-002352	Non-Cancerous	CCLE	DEPYEAIVPEM	DEG_COP1_1	0.1389
p.A155S	SIDM00466	Ovarian Carcinoma	GDSC	DEPYEAIVPEM	DEG_COP1_1	0.6477
p.A155S	SIDM00585	Hepatocellular Carcinoma	GDSC	DEPYEAIVPEM	DEG_COP1_1	0.6477
p.A155S	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	DEPYEAIVPEM	DEG_COP1_1	0.6477
p.A155S	SIDM00469	Pancreatic Carcinoma	GDSC	DEPYEAIVPEM	DEG_COP1_1	0.6477
p.A155S	ACH-000320	Pancreatic Cancer	CCLE	DEPYEAIVPEM	DEG_COP1_1	0.6477
p.A155S	ACH-000443	Ovarian Cancer	CCLE	DEPYEAIVPEM	DEG_COP1_1	0.6477
p.A155S	ACH-000480	Liver Cancer	CCLE	DEPYEAIVPEM	DEG_COP1_1	0.6477
p.A155S	ACH-000917	Esophageal Cancer	CCLE	DEPYEAIVPEM	DEG_COP1_1	0.6477
p.A155S	ACH-001060	Lymphoma	CCLE	DEPYEAIVPEM	DEG_COP1_1	0.6477
p.T165A	SIDM00217	Colorectal Carcinoma	GDSC	DEPYEAIVPEM	DEG_COP1_1	0.1944
p.T165A	ACH-000999	Colon/Colorectal Cancer	CCLE	DEPYEAIVPEM	DEG_COP1_1	0.1944
p.T165A	SNU-1040	large_intestine	COSMIC	DEPYEAIVPEM	DEG_COP1_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DEPYEAIVPEM

Degron related mutations and impact score

Drug responses associated with CDH19 mutations

All proteins holding degron of DEPYEAIVPEM

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H159	Cadherin-19	DEG_COP1_1	150:160	DEPYEAIVPEM	COP1	0.8019	More...