DegronMD - Q9H175(CSRNP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P486A	TCGA-33-6738	LUSC	TCGA	VGKTPTLE	DEG_SCF_FBW7_2	475:482	Mutation rewiring degron network	0.2222
p.P486A	DO26516	LUSC	ICGC	VGKTPTLE	DEG_SCF_FBW7_2	475:482	Mutation rewiring degron network	0.2222
p.S473A	TCGA-69-7763	LUAD	TCGA	VGKTPTLE	DEG_SCF_FBW7_2	475:482	Mutation rewiring degron network	0.2778
p.S473A	DO24616	LUAD	ICGC	VGKTPTLE	DEG_SCF_FBW7_2	475:482	Mutation rewiring degron network	0.2778
p.E487K	TCGA-AA-3984	COAD	TCGA	VGKTPTLE	DEG_SCF_FBW7_2	475:482	Mutation rewiring degron network	0.1944
p.E487K	DO9002	COAD	ICGC	VGKTPTLE	DEG_SCF_FBW7_2	475:482	Mutation rewiring degron network	0.1944
p.E487K	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VGKTPTLE	DEG_SCF_FBW7_2	475:482	Mutation rewiring degron network	0.1944
p.D488Y	TCGA-B5-A0JY	UCEC	TCGA	VGKTPTLE	DEG_SCF_FBW7_2	475:482	Mutation rewiring degron network	0.1667
p.D488Y	DO43041	UCEC	ICGC	VGKTPTLE	DEG_SCF_FBW7_2	475:482	Mutation rewiring degron network	0.1667
p.P491S	TCGA-EE-A29E	SKCM	TCGA	VGKTPTLE	DEG_SCF_FBW7_2	475:482	Mutation rewiring degron network	0.0833
p.P491S	DO37831	SKCM	ICGC	VGKTPTLE	DEG_SCF_FBW7_2	475:482	Mutation rewiring degron network	0.0833
p.L485S	TCGA-OR-A5LJ	ACC	TCGA	VGKTPTLE	DEG_SCF_FBW7_2	475:482	Mutation rewiring degron network	0.25
p.K472T	DO228350	BRCA	ICGC	VGKTPTLE	DEG_SCF_FBW7_2	475:482	Mutation substituting flanking lysine	0.3611
p.L481V	SIDM00672	Hepatocellular Carcinoma	GDSC	VGKTPTLE	DEG_SCF_FBW7_2	475:482	Mutation altering degron motif	0.5654
p.L481V	SIDM00454	Rhabdomyosarcoma	GDSC	VGKTPTLE	DEG_SCF_FBW7_2	475:482	Mutation altering degron motif	0.5654
p.L481V	SIDM00426	Rhabdomyosarcoma	GDSC	VGKTPTLE	DEG_SCF_FBW7_2	475:482	Mutation altering degron motif	0.5654
p.L481V	SIDM00954	Breast Carcinoma	GDSC	VGKTPTLE	DEG_SCF_FBW7_2	475:482	Mutation altering degron motif	0.5654
p.S473L	SIDM00683	Prostate Carcinoma	GDSC	VGKTPTLE	DEG_SCF_FBW7_2	475:482	Mutation rewiring degron network	0.2778
p.S473L	ACH-000977	lymph node	CCLE	VGKTPTLE	DEG_SCF_FBW7_2	475:482	Mutation rewiring degron network	0.2778
p.S473L	LNCaP-Clone-FGC	prostate	COSMIC	VGKTPTLE	DEG_SCF_FBW7_2	475:482	Mutation rewiring degron network	0.2778
p.A483T	SIDM01638	Non-Cancerous	GDSC	VGKTPTLE	DEG_SCF_FBW7_2	475:482	Mutation rewiring degron network	0.3056
p.A483T	ACH-002342	Non-Cancerous	CCLE	VGKTPTLE	DEG_SCF_FBW7_2	475:482	Mutation rewiring degron network	0.3056
p.T478K	ACH-001513	Cervical Cancer	CCLE	VGKTPTLE	DEG_SCF_FBW7_2	475:482	Mutation altering degron motif	0.7306

Kaplan plot for CSRNP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CSRNP2

UniProt ID: Q9H175

Entrez ID: 81566

Protein name: Cysteine/serine-rich nuclear protein 2 (CSRNP-2) (Protein FAM130A1) (TGF-beta-induced apoptosis protein 12) (TAIP-12)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CSRNP2 in