DegronMD

Uniprot ID: Q9H175

Source protein: Cysteine/serine-rich nuclear protein 2

Source gene: CSRNP2

Class: DEG_SCF_FBW7_2

Location: 475:482

E3 ligase: FBXW7

DEGRON score: 0.8308

ASA_SCORE: 73.175

COIL: 0.7103

CONS_SCORE: 0.3617

DSS_SCORE: 0.4151

HELIX: 0.2335

FCONS_SCORE: 1.0282

RIG_SCORE: 0.7288

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P486A	TCGA-33-6738	LUSC	TCGA	VGKTPTLE	DEG_SCF_FBW7_2	0.2222
p.P486A	DO26516	LUSC	ICGC	VGKTPTLE	DEG_SCF_FBW7_2	0.2222
p.S473A	TCGA-69-7763	LUAD	TCGA	VGKTPTLE	DEG_SCF_FBW7_2	0.2778
p.S473A	DO24616	LUAD	ICGC	VGKTPTLE	DEG_SCF_FBW7_2	0.2778
p.E487K	TCGA-AA-3984	COAD	TCGA	VGKTPTLE	DEG_SCF_FBW7_2	0.1944
p.E487K	DO9002	COAD	ICGC	VGKTPTLE	DEG_SCF_FBW7_2	0.1944
p.E487K	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VGKTPTLE	DEG_SCF_FBW7_2	0.1944
p.D488Y	TCGA-B5-A0JY	UCEC	TCGA	VGKTPTLE	DEG_SCF_FBW7_2	0.1667
p.D488Y	DO43041	UCEC	ICGC	VGKTPTLE	DEG_SCF_FBW7_2	0.1667
p.P491S	TCGA-EE-A29E	SKCM	TCGA	VGKTPTLE	DEG_SCF_FBW7_2	0.0833
p.P491S	DO37831	SKCM	ICGC	VGKTPTLE	DEG_SCF_FBW7_2	0.0833
p.L485S	TCGA-OR-A5LJ	ACC	TCGA	VGKTPTLE	DEG_SCF_FBW7_2	0.25
p.K472T	DO228350	BRCA	ICGC	VGKTPTLE	DEG_SCF_FBW7_2	0.3611
p.L481V	SIDM00672	Hepatocellular Carcinoma	GDSC	VGKTPTLE	DEG_SCF_FBW7_2	0.5654
p.L481V	SIDM00454	Rhabdomyosarcoma	GDSC	VGKTPTLE	DEG_SCF_FBW7_2	0.5654
p.L481V	SIDM00426	Rhabdomyosarcoma	GDSC	VGKTPTLE	DEG_SCF_FBW7_2	0.5654
p.L481V	SIDM00954	Breast Carcinoma	GDSC	VGKTPTLE	DEG_SCF_FBW7_2	0.5654
p.S473L	SIDM00683	Prostate Carcinoma	GDSC	VGKTPTLE	DEG_SCF_FBW7_2	0.2778
p.S473L	ACH-000977	lymph_node	CCLE	VGKTPTLE	DEG_SCF_FBW7_2	0.2778
p.S473L	LNCaP-Clone-FGC	prostate	COSMIC	VGKTPTLE	DEG_SCF_FBW7_2	0.2778
p.A483T	SIDM01638	Non-Cancerous	GDSC	VGKTPTLE	DEG_SCF_FBW7_2	0.3056
p.A483T	ACH-002342	Non-Cancerous	CCLE	VGKTPTLE	DEG_SCF_FBW7_2	0.3056
p.T478K	ACH-001513	Cervical Cancer	CCLE	VGKTPTLE	DEG_SCF_FBW7_2	0.7306

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H175	Cysteine/serine-rich nuclear protein 2	DEG_SCF_FBW7_2	475:482	VGKTPTLE	FBXW7	0.8308	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons