DegronMD - Q9H1M3(DEFB129)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P124H	TCGA-77-A5G8	LUSC	TCGA	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.7694
p.P124H	DO50099	LUSC	ICGC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.7694
p.T132N	TCGA-A5-A0G1	UCEC	TCGA	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation rewiring degron network	0.1944
p.T132N	DO42472	UCEC	ICGC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation rewiring degron network	0.1944
p.A122V	DO229013	COCA	ICGC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	DO229480	LAML	ICGC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	DO52365	LUSC	ICGC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00608	Plasma Cell Myeloma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00961	Ewing's Sarcoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00194	Colorectal Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00570	Gastric Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00338	Acute Myeloid Leukemia	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00353	Other Sarcomas	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM01034	B-Lymphoblastic Leukemia	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00373	Endometrial Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00615	Hepatocellular Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM01151	Hepatocellular Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00611	Kidney Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00614	Hepatocellular Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM01117	Small Cell Lung Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00781	Colorectal Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00157	Neuroblastoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00367	Small Cell Lung Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00553	Acute Myeloid Leukemia	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM01144	Gastric Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00590	Oral Cavity Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00466	Ovarian Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00060	Ovarian Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00287	B-Lymphoblastic Leukemia	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00235	Kidney Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00599	Osteosarcoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00487	Colorectal Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00489	Oral Cavity Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00292	Small Cell Lung Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00410	Other Blood Cancers	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00567	Other Solid Cancers	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM01019	Acute Myeloid Leukemia	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00280	Gastric Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00018	Acute Myeloid Leukemia	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00618	Hepatocellular Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00566	Oral Cavity Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00380	Acute Myeloid Leukemia	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00554	Ovarian Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00302	Other Solid Cancers	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00604	Oral Cavity Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00243	Other Solid Cancers	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00359	Colorectal Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM01582	Gastric Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM01335	Kidney Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM01511	Gastric Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM01622	Breast Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM01444	Glioblastoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00170	Head and Neck Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00158	Glioblastoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00780	Colorectal Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00161	Biliary Tract Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM01446	Glioblastoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM01378	Ovarian Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00164	Biliary Tract Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00171	Colorectal Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM01774	Pancreatic Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.A122V	SIDM00159	Biliary Tract Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation altering degron motif	0.5825
p.F116V	DO233238	GACA	ICGC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation rewiring degron network	0.2222
p.Q137E	SIDM01265	Plasma Cell Myeloma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation rewiring degron network	0.0556
p.Q137E	SIDM00672	Hepatocellular Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation rewiring degron network	0.0556
p.Q137E	SIDM00773	Non-Cancerous	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation rewiring degron network	0.0556
p.Q137E	SIDM00845	Burkitt's Lymphoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation rewiring degron network	0.0556
p.Q137E	SIDM00454	Rhabdomyosarcoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation rewiring degron network	0.0556
p.Q137E	SIDM00266	Ewing's Sarcoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation rewiring degron network	0.0556
p.Q137E	SIDM00690	Head and Neck Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation rewiring degron network	0.0556
p.Q137E	SIDM00694	Other Solid Cancers	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation rewiring degron network	0.0556
p.Q137E	SIDM00878	Breast Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation rewiring degron network	0.0556
p.Q137E	SIDM00971	Breast Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation rewiring degron network	0.0556
p.Q137E	SIDM00907	Burkitt's Lymphoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation rewiring degron network	0.0556
p.Q137E	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation rewiring degron network	0.0556
p.Q137E	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation rewiring degron network	0.0556
p.Q137E	SIDM00774	Breast Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation rewiring degron network	0.0556
p.Q137E	SIDM00808	Burkitt's Lymphoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation rewiring degron network	0.0556
p.Q137E	SIDM00638	Cervical Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation rewiring degron network	0.0556
p.Q137E	SIDM01173	Rhabdomyosarcoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation rewiring degron network	0.0556
p.Q137E	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation rewiring degron network	0.0556
p.Q137E	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation rewiring degron network	0.0556
p.Q137E	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation rewiring degron network	0.0556
p.Q137E	SIDM01387	Small Cell Lung Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation rewiring degron network	0.0556
p.Q137E	SIDM01254	Burkitt's Lymphoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation rewiring degron network	0.0556
p.Q137E	SIDM01525	Acute Myeloid Leukemia	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation rewiring degron network	0.0556
p.M133V	SIDM00251	Gastric Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation rewiring degron network	0.1667
p.M133V	ACH-000949	Gastric Cancer	CCLE	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation rewiring degron network	0.1667
p.M133V	TGBC11TKB	stomach	COSMIC	PNATPMNS	DEG_SCF_FBW7_1	120:127	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DEFB129

UniProt ID: Q9H1M3

Entrez ID: 140881

Protein name: Beta-defensin 129 (Beta-defensin 29) (DEFB-29) (Defensin, beta 129)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DEFB129 in