DegronMD

Uniprot ID: Q9H1M3

Source protein: Beta-defensin 129

Source gene: DEFB129

Class: DEG_SCF_FBW7_1

Location: 120:127

E3 ligase: FBXW7

DEGRON score: 0.9638

ASA_SCORE: 67.5875

COIL: 0.8348

CONS_SCORE: 0.6848

DSS_SCORE: 0.2493

HELIX: 0.0604

FCONS_SCORE: 1.3566

RIG_SCORE: 0.778

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P124H	TCGA-77-A5G8	LUSC	TCGA	PNATPMNS	DEG_SCF_FBW7_1	0.7694
p.P124H	DO50099	LUSC	ICGC	PNATPMNS	DEG_SCF_FBW7_1	0.7694
p.T132N	TCGA-A5-A0G1	UCEC	TCGA	PNATPMNS	DEG_SCF_FBW7_1	0.1944
p.T132N	DO42472	UCEC	ICGC	PNATPMNS	DEG_SCF_FBW7_1	0.1944
p.A122V	DO229013	COCA	ICGC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	DO229480	LAML	ICGC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	DO52365	LUSC	ICGC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00608	Plasma Cell Myeloma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00961	Ewing's Sarcoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00194	Colorectal Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00570	Gastric Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00338	Acute Myeloid Leukemia	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00353	Other Sarcomas	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM01034	B-Lymphoblastic Leukemia	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00373	Endometrial Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00615	Hepatocellular Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM01151	Hepatocellular Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00611	Kidney Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00614	Hepatocellular Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM01117	Small Cell Lung Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00781	Colorectal Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00157	Neuroblastoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00367	Small Cell Lung Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00553	Acute Myeloid Leukemia	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM01144	Gastric Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00590	Oral Cavity Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00466	Ovarian Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00060	Ovarian Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00287	B-Lymphoblastic Leukemia	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00235	Kidney Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00599	Osteosarcoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00487	Colorectal Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00489	Oral Cavity Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00292	Small Cell Lung Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00410	Other Blood Cancers	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00567	Other Solid Cancers	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM01019	Acute Myeloid Leukemia	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00280	Gastric Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00018	Acute Myeloid Leukemia	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00618	Hepatocellular Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00566	Oral Cavity Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00380	Acute Myeloid Leukemia	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00554	Ovarian Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00302	Other Solid Cancers	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00604	Oral Cavity Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00243	Other Solid Cancers	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00359	Colorectal Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM01582	Gastric Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM01335	Kidney Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM01511	Gastric Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM01622	Breast Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM01444	Glioblastoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00170	Head and Neck Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00158	Glioblastoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00780	Colorectal Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00161	Biliary Tract Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM01446	Glioblastoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM01378	Ovarian Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00164	Biliary Tract Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00171	Colorectal Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM01774	Pancreatic Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.A122V	SIDM00159	Biliary Tract Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.5825
p.F116V	DO233238	GACA	ICGC	PNATPMNS	DEG_SCF_FBW7_1	0.2222
p.Q137E	SIDM01265	Plasma Cell Myeloma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.0556
p.Q137E	SIDM00672	Hepatocellular Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.0556
p.Q137E	SIDM00773	Non-Cancerous	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.0556
p.Q137E	SIDM00845	Burkitt's Lymphoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.0556
p.Q137E	SIDM00454	Rhabdomyosarcoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.0556
p.Q137E	SIDM00266	Ewing's Sarcoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.0556
p.Q137E	SIDM00690	Head and Neck Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.0556
p.Q137E	SIDM00694	Other Solid Cancers	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.0556
p.Q137E	SIDM00878	Breast Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.0556
p.Q137E	SIDM00971	Breast Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.0556
p.Q137E	SIDM00907	Burkitt's Lymphoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.0556
p.Q137E	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.0556
p.Q137E	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.0556
p.Q137E	SIDM00774	Breast Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.0556
p.Q137E	SIDM00808	Burkitt's Lymphoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.0556
p.Q137E	SIDM00638	Cervical Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.0556
p.Q137E	SIDM01173	Rhabdomyosarcoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.0556
p.Q137E	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.0556
p.Q137E	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.0556
p.Q137E	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.0556
p.Q137E	SIDM01387	Small Cell Lung Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.0556
p.Q137E	SIDM01254	Burkitt's Lymphoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.0556
p.Q137E	SIDM01525	Acute Myeloid Leukemia	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.0556
p.M133V	SIDM00251	Gastric Carcinoma	GDSC	PNATPMNS	DEG_SCF_FBW7_1	0.1667
p.M133V	ACH-000949	Gastric Cancer	CCLE	PNATPMNS	DEG_SCF_FBW7_1	0.1667
p.M133V	TGBC11TKB	stomach	COSMIC	PNATPMNS	DEG_SCF_FBW7_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PNATPMNS

Degron related mutations and impact score

Drug responses associated with DEFB129 mutations

All proteins holding degron of PNATPMNS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H1M3	Beta-defensin 129	DEG_SCF_FBW7_1	120:127	PNATPMNS	FBXW7	0.9638	More...