DegronMD - Q9H221(ABCG8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D33G	TCGA-43-7656	LUSC	TCGA	NSLYFTYSGQP	CBL_PTK	34:44	Mutation rewiring degron network	0.3056
p.D33G	DO26424	LUSC	ICGC	NSLYFTYSGQP	CBL_PTK	34:44	Mutation rewiring degron network	0.3056
p.F28L	TCGA-A5-A1OF	UCEC	TCGA	NSLYFTYSGQP	CBL_PTK	34:44	Mutation rewiring degron network	0.1667
p.F28L	DO42568	UCEC	ICGC	NSLYFTYSGQP	CBL_PTK	34:44	Mutation rewiring degron network	0.1667
p.D25N	TCGA-D9-A3Z1	SKCM	TCGA	NSLYFTYSGQP	CBL_PTK	34:44	Mutation rewiring degron network	0.0833
p.D25N	DO38105	SKCM	ICGC	NSLYFTYSGQP	CBL_PTK	34:44	Mutation rewiring degron network	0.0833
p.Q24H	TCGA-DU-6392	LGG	TCGA	NSLYFTYSGQP	CBL_PTK	34:44	Mutation rewiring degron network	0.0556
p.Q24H	DO22237	LGG	ICGC	NSLYFTYSGQP	CBL_PTK	34:44	Mutation rewiring degron network	0.0556
p.E31K	TCGA-EE-A3AE	SKCM	TCGA	NSLYFTYSGQP	CBL_PTK	34:44	Mutation rewiring degron network	0.25
p.E31K	DO37802	SKCM	ICGC	NSLYFTYSGQP	CBL_PTK	34:44	Mutation rewiring degron network	0.25
p.E31K	SIDM00935	Other Solid Cancers	GDSC	NSLYFTYSGQP	CBL_PTK	34:44	Mutation rewiring degron network	0.25
p.E31K	ACH-002091	Skin Cancer	CCLE	NSLYFTYSGQP	CBL_PTK	34:44	Mutation rewiring degron network	0.25
p.E31K	CAL-39	vulva	COSMIC	NSLYFTYSGQP	CBL_PTK	34:44	Mutation rewiring degron network	0.25
p.R26K	TCGA-EO-A22X	UCEC	TCGA	NSLYFTYSGQP	CBL_PTK	34:44	Mutation rewiring degron network	0.1111
p.R26K	DO43907	UCEC	ICGC	NSLYFTYSGQP	CBL_PTK	34:44	Mutation rewiring degron network	0.1111
p.Y54C	DO229010	COCA	ICGC	NSLYFTYSGQP	CBL_PTK	34:44	Mutation rewiring degron network	0.0556
p.Y54C	DO229013	COCA	ICGC	NSLYFTYSGQP	CBL_PTK	34:44	Mutation rewiring degron network	0.0556
p.Y54C	DO229016	COCA	ICGC	NSLYFTYSGQP	CBL_PTK	34:44	Mutation rewiring degron network	0.0556
p.Y54C	DO229003	COCA	ICGC	NSLYFTYSGQP	CBL_PTK	34:44	Mutation rewiring degron network	0.0556
p.Y54C	DO229005	COCA	ICGC	NSLYFTYSGQP	CBL_PTK	34:44	Mutation rewiring degron network	0.0556
p.Y54C	DO234285	ESAD	ICGC	NSLYFTYSGQP	CBL_PTK	34:44	Mutation rewiring degron network	0.0556
p.S35I	DO231830	LINC	ICGC	NSLYFTYSGQP	CBL_PTK	34:44	Mutation altering degron motif	0.623
p.V49I	DO220891	MELA	ICGC	NSLYFTYSGQP	CBL_PTK	34:44	Mutation rewiring degron network	0.1944
p.S32G	SIDM00454	Rhabdomyosarcoma	GDSC	NSLYFTYSGQP	CBL_PTK	34:44	Mutation rewiring degron network	0.2778
p.S32G	SIDM00971	Breast Carcinoma	GDSC	NSLYFTYSGQP	CBL_PTK	34:44	Mutation rewiring degron network	0.2778
p.S32G	SIDM00032	Bladder Carcinoma	GDSC	NSLYFTYSGQP	CBL_PTK	34:44	Mutation rewiring degron network	0.2778
p.S41T	SIDM00777	Colorectal Carcinoma	GDSC	NSLYFTYSGQP	CBL_PTK	34:44	Mutation altering degron motif	0.6005
p.S41T	ACH-000360	Colon/Colorectal Cancer	CCLE	NSLYFTYSGQP	CBL_PTK	34:44	Mutation altering degron motif	0.6005
p.S41T	NCI-H508	large intestine	COSMIC	NSLYFTYSGQP	CBL_PTK	34:44	Mutation altering degron motif	0.6005
p.L52V	SIDM00654	Small Cell Lung Carcinoma	GDSC	NSLYFTYSGQP	CBL_PTK	34:44	Mutation rewiring degron network	0.1111
p.L52V	SIDM00210	Ovarian Carcinoma	GDSC	NSLYFTYSGQP	CBL_PTK	34:44	Mutation rewiring degron network	0.1111
p.N34K	SIDM00879	Breast Carcinoma	GDSC	NSLYFTYSGQP	CBL_PTK	34:44	Mutation altering degron motif	0.6918
p.N34K	ACH-000349	Breast Cancer	CCLE	NSLYFTYSGQP	CBL_PTK	34:44	Mutation altering degron motif	0.6918
p.N34K	HCC1500	breast	COSMIC	NSLYFTYSGQP	CBL_PTK	34:44	Mutation altering degron motif	0.6918
p.D33N	SIDM00954	Breast Carcinoma	GDSC	NSLYFTYSGQP	CBL_PTK	34:44	Mutation rewiring degron network	0.3056

Kaplan plot for ABCG8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ABCG8

UniProt ID: Q9H221

Entrez ID: 64241

Protein name: ATP-binding cassette sub-family G member 8 (EC 7.6.2.-) (Sterolin-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ABCG8 in