DegronMD

Uniprot ID: Q9H221

Source protein: ATP-binding cassette sub-family G member 8

Source gene: ABCG8

Class: CBL_PTK

Location: 34:44

E3 ligase: CBL

DEGRON score: 0.9709

ASA_SCORE: 78.4273

COIL: 0.8033

CONS_SCORE: 0.3556

DSS_SCORE: 0.3871

HELIX: 0.104

FCONS_SCORE: 0.966

RIG_SCORE: 0.7437

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D33G	TCGA-43-7656	LUSC	TCGA	NSLYFTYSGQP	CBL_PTK	0.3056
p.D33G	DO26424	LUSC	ICGC	NSLYFTYSGQP	CBL_PTK	0.3056
p.F28L	TCGA-A5-A1OF	UCEC	TCGA	NSLYFTYSGQP	CBL_PTK	0.1667
p.F28L	DO42568	UCEC	ICGC	NSLYFTYSGQP	CBL_PTK	0.1667
p.D25N	TCGA-D9-A3Z1	SKCM	TCGA	NSLYFTYSGQP	CBL_PTK	0.0833
p.D25N	DO38105	SKCM	ICGC	NSLYFTYSGQP	CBL_PTK	0.0833
p.Q24H	TCGA-DU-6392	LGG	TCGA	NSLYFTYSGQP	CBL_PTK	0.0556
p.Q24H	DO22237	LGG	ICGC	NSLYFTYSGQP	CBL_PTK	0.0556
p.E31K	TCGA-EE-A3AE	SKCM	TCGA	NSLYFTYSGQP	CBL_PTK	0.25
p.E31K	DO37802	SKCM	ICGC	NSLYFTYSGQP	CBL_PTK	0.25
p.E31K	SIDM00935	Other Solid Cancers	GDSC	NSLYFTYSGQP	CBL_PTK	0.25
p.E31K	ACH-002091	Skin Cancer	CCLE	NSLYFTYSGQP	CBL_PTK	0.25
p.E31K	CAL-39	vulva	COSMIC	NSLYFTYSGQP	CBL_PTK	0.25
p.R26K	TCGA-EO-A22X	UCEC	TCGA	NSLYFTYSGQP	CBL_PTK	0.1111
p.R26K	DO43907	UCEC	ICGC	NSLYFTYSGQP	CBL_PTK	0.1111
p.Y54C	DO229010	COCA	ICGC	NSLYFTYSGQP	CBL_PTK	0.0556
p.Y54C	DO229013	COCA	ICGC	NSLYFTYSGQP	CBL_PTK	0.0556
p.Y54C	DO229016	COCA	ICGC	NSLYFTYSGQP	CBL_PTK	0.0556
p.Y54C	DO229003	COCA	ICGC	NSLYFTYSGQP	CBL_PTK	0.0556
p.Y54C	DO229005	COCA	ICGC	NSLYFTYSGQP	CBL_PTK	0.0556
p.Y54C	DO234285	ESAD	ICGC	NSLYFTYSGQP	CBL_PTK	0.0556
p.S35I	DO231830	LINC	ICGC	NSLYFTYSGQP	CBL_PTK	0.623
p.V49I	DO220891	MELA	ICGC	NSLYFTYSGQP	CBL_PTK	0.1944
p.S32G	SIDM00454	Rhabdomyosarcoma	GDSC	NSLYFTYSGQP	CBL_PTK	0.2778
p.S32G	SIDM00971	Breast Carcinoma	GDSC	NSLYFTYSGQP	CBL_PTK	0.2778
p.S32G	SIDM00032	Bladder Carcinoma	GDSC	NSLYFTYSGQP	CBL_PTK	0.2778
p.S41T	SIDM00777	Colorectal Carcinoma	GDSC	NSLYFTYSGQP	CBL_PTK	0.6005
p.S41T	ACH-000360	Colon/Colorectal Cancer	CCLE	NSLYFTYSGQP	CBL_PTK	0.6005
p.S41T	NCI-H508	large_intestine	COSMIC	NSLYFTYSGQP	CBL_PTK	0.6005
p.L52V	SIDM00654	Small Cell Lung Carcinoma	GDSC	NSLYFTYSGQP	CBL_PTK	0.1111
p.L52V	SIDM00210	Ovarian Carcinoma	GDSC	NSLYFTYSGQP	CBL_PTK	0.1111
p.N34K	SIDM00879	Breast Carcinoma	GDSC	NSLYFTYSGQP	CBL_PTK	0.6918
p.N34K	ACH-000349	Breast Cancer	CCLE	NSLYFTYSGQP	CBL_PTK	0.6918
p.N34K	HCC1500	breast	COSMIC	NSLYFTYSGQP	CBL_PTK	0.6918
p.D33N	SIDM00954	Breast Carcinoma	GDSC	NSLYFTYSGQP	CBL_PTK	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NSLYFTYSGQP

Degron related mutations and impact score

Drug responses associated with ABCG8 mutations

All proteins holding degron of NSLYFTYSGQP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H221	ATP-binding cassette sub-family G member 8	CBL_PTK	34:44	NSLYFTYSGQP	CBL	0.9709	More...