DegronMD - Q9H2A9(CHST8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R50S	TCGA-55-7570	LUAD	TCGA	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	37:49	Mutation rewiring degron network	0.3056
p.R50S	DO25280	LUAD	ICGC	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	37:49	Mutation rewiring degron network	0.3056
p.A38T	TCGA-EJ-5511	PRAD	TCGA	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	37:49	Mutation altering degron motif	0.7139
p.A38T	DO36324	PRAD	ICGC	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	37:49	Mutation altering degron motif	0.7139
p.A38T	SIDM00216	Colorectal Carcinoma	GDSC	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	37:49	Mutation altering degron motif	0.7139
p.A38T	ACH-000989	Colon/Colorectal Cancer	CCLE	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	37:49	Mutation altering degron motif	0.7139
p.A38T	SNU-175	large intestine	COSMIC	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	37:49	Mutation altering degron motif	0.7139
p.T35M	TCGA-F4-6855	COAD	TCGA	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	37:49	Mutation rewiring degron network	0.2778
p.T35M	DO8025	COAD	ICGC	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	37:49	Mutation rewiring degron network	0.2778
p.T35M	DO234187	ESAD	ICGC	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	37:49	Mutation rewiring degron network	0.2778
p.T35M	ACH-001518	Endometrial/Uterine Cancer	CCLE	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	37:49	Mutation rewiring degron network	0.2778
p.E36D	TCGA-FG-A710	LGG	TCGA	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	37:49	Mutation rewiring degron network	0.3056
p.E36D	DO48494	LGG	ICGC	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	37:49	Mutation rewiring degron network	0.3056
p.P39L	DO936	BOCA	ICGC	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	37:49	Mutation altering degron motif	0.7582
p.R52M	DO229031	LICA	ICGC	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	37:49	Mutation rewiring degron network	0.25
p.P34H	DO35242	PACA	ICGC	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	37:49	Mutation rewiring degron network	0.25
p.L27F	DO229502	SKCA	ICGC	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	37:49	Mutation rewiring degron network	0.0556
p.H56Q	SIDM00469	Pancreatic Carcinoma	GDSC	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	37:49	Mutation rewiring degron network	0.1389
p.H56Q	PSN1	pancreas	COSMIC	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	37:49	Mutation rewiring degron network	0.1389
p.D33Y	SIDM00743	Non-Small Cell Lung Carcinoma	GDSC	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	37:49	Mutation rewiring degron network	0.2222
p.D33Y	ACH-000448	Lung Cancer	CCLE	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	37:49	Mutation rewiring degron network	0.2222
p.D33Y	NCI-H1666	lung	COSMIC	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	37:49	Mutation rewiring degron network	0.2222
p.L58I	ACH-002025	Colon/Colorectal Cancer	CCLE	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	37:49	Mutation rewiring degron network	0.0833
p.P59L	ACH-002287	Colon/Colorectal Cancer	CCLE	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	37:49	Mutation rewiring degron network	0.0556
p.P59L	NCI-H630	large intestine	COSMIC	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	37:49	Mutation rewiring degron network	0.0556

Kaplan plot for CHST8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CHST8

UniProt ID: Q9H2A9

Entrez ID: 64377

Protein name: Carbohydrate sulfotransferase 8 (EC 2.8.2.-) (GalNAc-4-O-sulfotransferase 1) (GalNAc-4-ST1) (GalNAc4ST-1) (N-acetylgalactosamine-4-O-sulfotransferase 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CHST8 in