DegronMD

Uniprot ID: Q9H2A9

Source protein: Carbohydrate sulfotransferase 8

Source gene: CHST8

Class: DEG_ODPH_VHL_1

Location: 37:49

E3 ligase: VHL

DEGRON score: 0.985

ASA_SCORE: 81.7923

COIL: 0.7609

CONS_SCORE: 0.3084

DSS_SCORE: 0.5056

HELIX: 0.0408

FCONS_SCORE: 0.9521

RIG_SCORE: 0.7346

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R50S	TCGA-55-7570	LUAD	TCGA	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	0.3056
p.R50S	DO25280	LUAD	ICGC	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	0.3056
p.A38T	TCGA-EJ-5511	PRAD	TCGA	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	0.7139
p.A38T	DO36324	PRAD	ICGC	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	0.7139
p.A38T	SIDM00216	Colorectal Carcinoma	GDSC	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	0.7139
p.A38T	ACH-000989	Colon/Colorectal Cancer	CCLE	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	0.7139
p.A38T	SNU-175	large_intestine	COSMIC	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	0.7139
p.T35M	TCGA-F4-6855	COAD	TCGA	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	0.2778
p.T35M	DO8025	COAD	ICGC	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	0.2778
p.T35M	DO234187	ESAD	ICGC	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	0.2778
p.T35M	ACH-001518	Endometrial/Uterine Cancer	CCLE	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	0.2778
p.E36D	TCGA-FG-A710	LGG	TCGA	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	0.3056
p.E36D	DO48494	LGG	ICGC	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	0.3056
p.P39L	DO936	BOCA	ICGC	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	0.7582
p.R52M	DO229031	LICA	ICGC	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	0.25
p.P34H	DO35242	PACA	ICGC	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	0.25
p.L27F	DO229502	SKCA	ICGC	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	0.0556
p.H56Q	SIDM00469	Pancreatic Carcinoma	GDSC	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	0.1389
p.H56Q	PSN1	pancreas	COSMIC	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	0.1389
p.D33Y	SIDM00743	Non-Small Cell Lung Carcinoma	GDSC	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	0.2222
p.D33Y	ACH-000448	Lung Cancer	CCLE	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	0.2222
p.D33Y	NCI-H1666	lung	COSMIC	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	0.2222
p.L58I	ACH-002025	Colon/Colorectal Cancer	CCLE	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	0.0833
p.P59L	ACH-002287	Colon/Colorectal Cancer	CCLE	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	0.0556
p.P59L	NCI-H630	large_intestine	COSMIC	LAPQQVPGIKFNI	DEG_ODPH_VHL_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2A9	Carbohydrate sulfotransferase 8	DEG_ODPH_VHL_1	37:49	LAPQQVPGIKFNI	VHL	0.985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPQQVPGIKFNI

Degron related mutations and impact score

Drug responses associated with CHST8 mutations

All proteins holding degron of LAPQQVPGIKFNI