DegronMD - Q9H2U2(PPA2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S61F	TCGA-A8-A0A7	BRCA	TCGA	ISPFHD	LIG_APCC_ABBA_1	60:65	Mutation altering degron motif	0.6871
p.S61F	DO5936	BRCA	ICGC	ISPFHD	LIG_APCC_ABBA_1	60:65	Mutation altering degron motif	0.6871
p.F63L	TCGA-BG-A0M4	UCEC	TCGA	ISPFHD	LIG_APCC_ABBA_1	60:65	Mutation altering degron motif	0.6981
p.F63L	DO41686	UCEC	ICGC	ISPFHD	LIG_APCC_ABBA_1	60:65	Mutation altering degron motif	0.6981
p.K53N	TCGA-BR-8680	STAD	TCGA	ISPFHD	LIG_APCC_ABBA_1	60:65	Mutation substituting flanking lysine	0.25
p.K53N	DO234246	ESAD	ICGC	ISPFHD	LIG_APCC_ABBA_1	60:65	Mutation substituting flanking lysine	0.25
p.K53N	DO47769	STAD	ICGC	ISPFHD	LIG_APCC_ABBA_1	60:65	Mutation substituting flanking lysine	0.25
p.P62L	TCGA-D3-A1QA	SKCM	TCGA	ISPFHD	LIG_APCC_ABBA_1	60:65	Mutation altering degron motif	0.6471
p.P62L	DO47469	SKCM	ICGC	ISPFHD	LIG_APCC_ABBA_1	60:65	Mutation altering degron motif	0.6471
p.L69F	DO49795	BLCA	ICGC	ISPFHD	LIG_APCC_ABBA_1	60:65	Mutation substituting flanking lysine	0.3333
p.L68V	DO1075	BRCA	ICGC	ISPFHD	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.25
p.L50P	DO233690	GACA	ICGC	ISPFHD	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.0556
p.N70K	DO38563	STAD	ICGC	ISPFHD	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.1944
p.H64Y	SIDM01768	Melanoma	GDSC	ISPFHD	LIG_APCC_ABBA_1	60:65	Mutation altering degron motif	0.6118
p.H64Y	ACH-000899	Skin Cancer	CCLE	ISPFHD	LIG_APCC_ABBA_1	60:65	Mutation altering degron motif	0.6118
p.R73K	NCI-H2029	lung	COSMIC	ISPFHD	LIG_APCC_ABBA_1	60:65	Mutation substituting flanking lysine	0.2222
p.L65M	MOG-G-UVW	central nervous system	COSMIC	ISPFHD	LIG_APCC_ABBA_1	60:65	Mutation altering degron motif	0.711
p.L65V	NCI-H2342	lung	COSMIC	ISPFHD	LIG_APCC_ABBA_1	60:65	Mutation altering degron motif	0.6765
p.D55N	SKG-IIIa	cervix	COSMIC	ISPFHD	LIG_APCC_ABBA_1	60:65	Mutation rewiring degron network	0.1944

Kaplan plot for PPA2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPA2

UniProt ID: Q9H2U2

Entrez ID: 27068

Protein name: Inorganic pyrophosphatase 2, mitochondrial (EC 3.6.1.1) (Pyrophosphatase SID6-306) (Pyrophosphate phospho-hydrolase 2) (PPase 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPA2 in