DegronMD

Uniprot ID: Q9H2U2

Source protein: Inorganic pyrophosphatase 2, mitochondrial

Source gene: PPA2

Class: LIG_APCC_ABBA_1

Location: 60:65

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7161

ASA_SCORE: 24.2667

COIL: 0.5548

CONS_SCORE: 0.6994

DSS_SCORE: 0.2592

HELIX: 0.0768

FCONS_SCORE: 1.5919

RIG_SCORE: 0.7875

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L65M	MOG-G-UVW	central_nervous_system	COSMIC	ISPFHD	LIG_APCC_ABBA_1	0.711
p.F63L	TCGA-BG-A0M4	UCEC	TCGA	ISPFHD	LIG_APCC_ABBA_1	0.6981
p.F63L	DO41686	UCEC	ICGC	ISPFHD	LIG_APCC_ABBA_1	0.6981
p.S61F	TCGA-A8-A0A7	BRCA	TCGA	ISPFHD	LIG_APCC_ABBA_1	0.6871
p.S61F	DO5936	BRCA	ICGC	ISPFHD	LIG_APCC_ABBA_1	0.6871
p.L65V	NCI-H2342	lung	COSMIC	ISPFHD	LIG_APCC_ABBA_1	0.6765
p.P62L	TCGA-D3-A1QA	SKCM	TCGA	ISPFHD	LIG_APCC_ABBA_1	0.6471
p.P62L	DO47469	SKCM	ICGC	ISPFHD	LIG_APCC_ABBA_1	0.6471
p.H64Y	SIDM01768	Melanoma	GDSC	ISPFHD	LIG_APCC_ABBA_1	0.6118
p.H64Y	ACH-000899	Skin Cancer	CCLE	ISPFHD	LIG_APCC_ABBA_1	0.6118
p.L69F	DO49795	BLCA	ICGC	ISPFHD	LIG_APCC_ABBA_1	0.3333
p.K53N	TCGA-BR-8680	STAD	TCGA	ISPFHD	LIG_APCC_ABBA_1	0.25
p.K53N	DO234246	ESAD	ICGC	ISPFHD	LIG_APCC_ABBA_1	0.25
p.K53N	DO47769	STAD	ICGC	ISPFHD	LIG_APCC_ABBA_1	0.25
p.L68V	DO1075	BRCA	ICGC	ISPFHD	LIG_APCC_ABBA_1	0.25
p.R73K	NCI-H2029	lung	COSMIC	ISPFHD	LIG_APCC_ABBA_1	0.2222
p.N70K	DO38563	STAD	ICGC	ISPFHD	LIG_APCC_ABBA_1	0.1944
p.D55N	SKG-IIIa	cervix	COSMIC	ISPFHD	LIG_APCC_ABBA_1	0.1944
p.L50P	DO233690	GACA	ICGC	ISPFHD	LIG_APCC_ABBA_1	0.0556

Showing 1 to 19 of 19 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2U2	Inorganic pyrophosphatase 2, mitochondrial	LIG_APCC_ABBA_1	60:65	ISPFHD	APC,CDC20,FZR1	0.7161	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons