DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ISPFHD
Uniprot ID:
Q9H2U2
Source protein:
Inorganic pyrophosphatase 2, mitochondrial
Source gene:
PPA2
Class:
LIG_APCC_ABBA_1
Location:
60:65
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7161
ASA_SCORE:
24.2667
COIL:
0.5548
CONS_SCORE:
0.6994
DSS_SCORE:
0.2592
HELIX:
0.0768
FCONS_SCORE:
1.5919
RIG_SCORE:
0.7875
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S61F
TCGA-A8-A0A7
BRCA
TCGA
ISPFHD
LIG_APCC_ABBA_1
0.6871
p.S61F
DO5936
BRCA
ICGC
ISPFHD
LIG_APCC_ABBA_1
0.6871
p.F63L
TCGA-BG-A0M4
UCEC
TCGA
ISPFHD
LIG_APCC_ABBA_1
0.6981
p.F63L
DO41686
UCEC
ICGC
ISPFHD
LIG_APCC_ABBA_1
0.6981
p.K53N
TCGA-BR-8680
STAD
TCGA
ISPFHD
LIG_APCC_ABBA_1
0.25
p.K53N
DO234246
ESAD
ICGC
ISPFHD
LIG_APCC_ABBA_1
0.25
p.K53N
DO47769
STAD
ICGC
ISPFHD
LIG_APCC_ABBA_1
0.25
p.P62L
TCGA-D3-A1QA
SKCM
TCGA
ISPFHD
LIG_APCC_ABBA_1
0.6471
p.P62L
DO47469
SKCM
ICGC
ISPFHD
LIG_APCC_ABBA_1
0.6471
p.L69F
DO49795
BLCA
ICGC
ISPFHD
LIG_APCC_ABBA_1
0.3333
p.L68V
DO1075
BRCA
ICGC
ISPFHD
LIG_APCC_ABBA_1
0.25
p.L50P
DO233690
GACA
ICGC
ISPFHD
LIG_APCC_ABBA_1
0.0556
p.N70K
DO38563
STAD
ICGC
ISPFHD
LIG_APCC_ABBA_1
0.1944
p.H64Y
SIDM01768
Melanoma
GDSC
ISPFHD
LIG_APCC_ABBA_1
0.6118
p.H64Y
ACH-000899
Skin Cancer
CCLE
ISPFHD
LIG_APCC_ABBA_1
0.6118
p.R73K
NCI-H2029
lung
COSMIC
ISPFHD
LIG_APCC_ABBA_1
0.2222
p.L65M
MOG-G-UVW
central_nervous_system
COSMIC
ISPFHD
LIG_APCC_ABBA_1
0.711
p.L65V
NCI-H2342
lung
COSMIC
ISPFHD
LIG_APCC_ABBA_1
0.6765
p.D55N
SKG-IIIa
cervix
COSMIC
ISPFHD
LIG_APCC_ABBA_1
0.1944
Drug responses associated with PPA2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ISPFHD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H2U2
Inorganic pyrophosphatase 2, mitochondrial
LIG_APCC_ABBA_1
60:65
ISPFHD
APC,CDC20,FZR1
0.7161
More...