DegronMD - Q9H2X0(CHRD)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R465C	TCGA-68-7757	LUSC	TCGA	QRTVLCHMA	DEG_APCC_DBOX_1	464:472	Mutation altering degron motif	0.8301
p.H479Y	TCGA-DD-AACU	LIHC	TCGA	QRTVLCHMA	DEG_APCC_DBOX_1	464:472	Mutation rewiring degron network	0.1389
p.A481T	TCGA-FI-A2D5	UCEC	TCGA	QRTVLCHMA	DEG_APCC_DBOX_1	464:472	Mutation rewiring degron network	0.0833
p.P480S	DO44037	BLCA	ICGC	QRTVLCHMA	DEG_APCC_DBOX_1	464:472	Mutation rewiring degron network	0.1111
p.R479Q	DO50008	HNSC	ICGC	QRTVLCHMA	DEG_APCC_DBOX_1	464:472	Mutation rewiring degron network	0.1389
p.S468N	DO50970	LICA	ICGC	QRTVLCHMA	DEG_APCC_DBOX_1	464:472	Mutation altering degron motif	0.7069
p.T457S	SIDM01203	Other Solid Cancers	GDSC	QRTVLCHMA	DEG_APCC_DBOX_1	464:472	Mutation rewiring degron network	0.1389
p.T457S	SIDM00198	Ewing's Sarcoma	GDSC	QRTVLCHMA	DEG_APCC_DBOX_1	464:472	Mutation rewiring degron network	0.1389
p.R462K	SIDM00845	Burkitt's Lymphoma	GDSC	QRTVLCHMA	DEG_APCC_DBOX_1	464:472	Mutation rewiring degron network	0.2778
p.D463N	SIDM00845	Burkitt's Lymphoma	GDSC	QRTVLCHMA	DEG_APCC_DBOX_1	464:472	Mutation rewiring degron network	0.3056
p.P476S	SIDM00954	Breast Carcinoma	GDSC	QRTVLCHMA	DEG_APCC_DBOX_1	464:472	Mutation rewiring degron network	0.2222
p.A480V	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	QRTVLCHMA	DEG_APCC_DBOX_1	464:472	Mutation rewiring degron network	0.1111
p.E460K	A101D	skin	COSMIC	QRTVLCHMA	DEG_APCC_DBOX_1	464:472	Mutation rewiring degron network	0.2222

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons