DegronMD

Uniprot ID: Q9H2X0

Source protein: Chordin

Source gene: CHRD

Class: DEG_APCC_DBOX_1

Location: 464:472

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6264

ASA_SCORE: 44.2667

COIL: 0.3229

CONS_SCORE: 0.3804

DSS_SCORE: 0.4375

HELIX: 0.0317

FCONS_SCORE: 0.8593

RIG_SCORE: 0.8279

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R465C	TCGA-68-7757	LUSC	TCGA	QRTVLCHMA	DEG_APCC_DBOX_1	0.8301
p.H479Y	TCGA-DD-AACU	LIHC	TCGA	QRTVLCHMA	DEG_APCC_DBOX_1	0.1389
p.A481T	TCGA-FI-A2D5	UCEC	TCGA	QRTVLCHMA	DEG_APCC_DBOX_1	0.0833
p.P480S	DO44037	BLCA	ICGC	QRTVLCHMA	DEG_APCC_DBOX_1	0.1111
p.R479Q	DO50008	HNSC	ICGC	QRTVLCHMA	DEG_APCC_DBOX_1	0.1389
p.S468N	DO50970	LICA	ICGC	QRTVLCHMA	DEG_APCC_DBOX_1	0.7069
p.T457S	SIDM01203	Other Solid Cancers	GDSC	QRTVLCHMA	DEG_APCC_DBOX_1	0.1389
p.T457S	SIDM00198	Ewing's Sarcoma	GDSC	QRTVLCHMA	DEG_APCC_DBOX_1	0.1389
p.R462K	SIDM00845	Burkitt's Lymphoma	GDSC	QRTVLCHMA	DEG_APCC_DBOX_1	0.2778
p.D463N	SIDM00845	Burkitt's Lymphoma	GDSC	QRTVLCHMA	DEG_APCC_DBOX_1	0.3056
p.P476S	SIDM00954	Breast Carcinoma	GDSC	QRTVLCHMA	DEG_APCC_DBOX_1	0.2222
p.A480V	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	QRTVLCHMA	DEG_APCC_DBOX_1	0.1111
p.E460K	A101D	skin	COSMIC	QRTVLCHMA	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2X0	Chordin	DEG_APCC_DBOX_1	464:472	QRTVLCHMA	APC,CDC20,FZR1	0.6264	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons