DegronMD - Q9H2X9(SLC12A5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K59N	TCGA-44-A4SS	LUAD	TCGA	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation substituting flanking lysine	0.1944
p.E62V	TCGA-50-5049	LUAD	TCGA	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation rewiring degron network	0.1667
p.E62V	DO23705	LUAD	ICGC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation rewiring degron network	0.1667
p.E62V	DO36556	READ	ICGC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation rewiring degron network	0.1667
p.P79H	TCGA-55-8203	LUAD	TCGA	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation rewiring degron network	0.1667
p.E58D	TCGA-AP-A059	UCEC	TCGA	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation rewiring degron network	0.0556
p.E58D	DO41361	UCEC	ICGC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation rewiring degron network	0.0556
p.E58D	SIDM01611	Endometrial Carcinoma	GDSC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation rewiring degron network	0.0556
p.K66N	TCGA-B5-A11E	UCEC	TCGA	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation rewiring degron network	0.2778
p.K66N	TCGA-C8-A26Y	BRCA	TCGA	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation rewiring degron network	0.2778
p.K66N	TCGA-EO-A3AV	UCEC	TCGA	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation rewiring degron network	0.2778
p.K66N	DO1273	BRCA	ICGC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation rewiring degron network	0.2778
p.K66N	DO52412	UCEC	ICGC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation rewiring degron network	0.2778
p.K66N	DO41644	UCEC	ICGC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation rewiring degron network	0.2778
p.E58K	TCGA-CN-6013	HNSC	TCGA	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation rewiring degron network	0.0556
p.E58K	DO15975	HNSC	ICGC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation rewiring degron network	0.0556
p.G65D	TCGA-EO-A22R	UCEC	TCGA	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation rewiring degron network	0.25
p.G65D	DO42713	UCEC	ICGC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation rewiring degron network	0.25
p.A69T	TCGA-EO-A22R	UCEC	TCGA	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation altering degron motif	0.6028
p.A69T	DO42713	UCEC	ICGC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation altering degron motif	0.6028
p.E73K	TCGA-FW-A3R5	SKCM	TCGA	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation altering degron motif	0.7022
p.Q58H	DO51903	BLCA	ICGC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation rewiring degron network	0.0556
p.K61T	DO222798	COCA	ICGC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation substituting flanking lysine	0.25
p.V63I	DO233115	GACA	ICGC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation rewiring degron network	0.1944
p.V63I	DO51166	GBM	ICGC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation rewiring degron network	0.1944
p.V63I	DO23452	LINC	ICGC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation rewiring degron network	0.1944
p.V63I	DO34344	PACA	ICGC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation rewiring degron network	0.1944
p.V63I	DO50431	PRAD	ICGC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation rewiring degron network	0.1944
p.V63I	DO38459	STAD	ICGC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation rewiring degron network	0.1944
p.G77V	DO229041	LICA	ICGC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation blocking phosphorylation signal	0.6667
p.V73M	DO45339	LUAD	ICGC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation altering degron motif	0.7208
p.G60R	DO222702	MELA	ICGC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation rewiring degron network	0.1111
p.A69P	DO29398	OV	ICGC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation altering degron motif	0.6392
p.G60E	DO229462	SKCA	ICGC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation rewiring degron network	0.1111
p.G74D	DO52412	UCEC	ICGC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation rewiring degron network	0.3056
p.S78N	SIDM01016	T-Lymphoblastic Leukemia	GDSC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation blocking phosphorylation signal	0.6389
p.S78N	SIDM01263	T-Lymphoblastic Leukemia	GDSC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation blocking phosphorylation signal	0.6389
p.S78N	Jurkat	haematopoietic and lymphoid tissue	COSMIC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation blocking phosphorylation signal	0.6389
p.K61N	SIDM00188	Kidney Carcinoma	GDSC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation substituting flanking lysine	0.25
p.K61N	HA7-RCC	kidney	COSMIC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation substituting flanking lysine	0.25
p.E72A	SIDM01220	Glioma	GDSC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation altering degron motif	0.659
p.E72A	LNZTA3WT4	central nervous system	COSMIC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation altering degron motif	0.659
p.G60V	SIDM00273	Glioblastoma	GDSC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation rewiring degron network	0.1111
p.G60V	GI-1	central nervous system	COSMIC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation rewiring degron network	0.1111
p.M80T	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	MALFEE	LIG_APCC_ABBA_1	68:73	Mutation rewiring degron network	0.1389

Kaplan plot for SLC12A5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC12A5

UniProt ID: Q9H2X9

Entrez ID: 57468

Protein name: Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (K-Cl cotransporter 2) (hKCC2) (Neuronal K-Cl cotransporter)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLC12A5 in