DegronMD: protein-targeted degradation, mutation and drug response to degrons
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CPH
CGC
Degron:
MALFEE
Uniprot ID:
Q9H2X9
Source protein:
Solute carrier family 12 member 5
Source gene:
SLC12A5
Class:
LIG_APCC_ABBA_1
Location:
68:73
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9945
ASA_SCORE:
77.9667
COIL:
0.4933
CONS_SCORE:
0.3591
DSS_SCORE:
0.5405
HELIX:
0.437
FCONS_SCORE:
1.2422
RIG_SCORE:
0.7978
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.K59N
TCGA-44-A4SS
LUAD
TCGA
MALFEE
LIG_APCC_ABBA_1
0.1944
p.E62V
TCGA-50-5049
LUAD
TCGA
MALFEE
LIG_APCC_ABBA_1
0.1667
p.E62V
DO23705
LUAD
ICGC
MALFEE
LIG_APCC_ABBA_1
0.1667
p.E62V
DO36556
READ
ICGC
MALFEE
LIG_APCC_ABBA_1
0.1667
p.P79H
TCGA-55-8203
LUAD
TCGA
MALFEE
LIG_APCC_ABBA_1
0.1667
p.E58D
TCGA-AP-A059
UCEC
TCGA
MALFEE
LIG_APCC_ABBA_1
0.0556
p.E58D
DO41361
UCEC
ICGC
MALFEE
LIG_APCC_ABBA_1
0.0556
p.E58D
SIDM01611
Endometrial Carcinoma
GDSC
MALFEE
LIG_APCC_ABBA_1
0.0556
p.K66N
TCGA-B5-A11E
UCEC
TCGA
MALFEE
LIG_APCC_ABBA_1
0.2778
p.K66N
TCGA-C8-A26Y
BRCA
TCGA
MALFEE
LIG_APCC_ABBA_1
0.2778
p.K66N
TCGA-EO-A3AV
UCEC
TCGA
MALFEE
LIG_APCC_ABBA_1
0.2778
p.K66N
DO1273
BRCA
ICGC
MALFEE
LIG_APCC_ABBA_1
0.2778
p.K66N
DO52412
UCEC
ICGC
MALFEE
LIG_APCC_ABBA_1
0.2778
p.K66N
DO41644
UCEC
ICGC
MALFEE
LIG_APCC_ABBA_1
0.2778
p.E58K
TCGA-CN-6013
HNSC
TCGA
MALFEE
LIG_APCC_ABBA_1
0.0556
p.E58K
DO15975
HNSC
ICGC
MALFEE
LIG_APCC_ABBA_1
0.0556
p.G65D
TCGA-EO-A22R
UCEC
TCGA
MALFEE
LIG_APCC_ABBA_1
0.25
p.G65D
DO42713
UCEC
ICGC
MALFEE
LIG_APCC_ABBA_1
0.25
p.A69T
TCGA-EO-A22R
UCEC
TCGA
MALFEE
LIG_APCC_ABBA_1
0.6028
p.A69T
DO42713
UCEC
ICGC
MALFEE
LIG_APCC_ABBA_1
0.6028
p.E73K
TCGA-FW-A3R5
SKCM
TCGA
MALFEE
LIG_APCC_ABBA_1
0.7022
p.Q58H
DO51903
BLCA
ICGC
MALFEE
LIG_APCC_ABBA_1
0.0556
p.K61T
DO222798
COCA
ICGC
MALFEE
LIG_APCC_ABBA_1
0.25
p.V63I
DO233115
GACA
ICGC
MALFEE
LIG_APCC_ABBA_1
0.1944
p.V63I
DO51166
GBM
ICGC
MALFEE
LIG_APCC_ABBA_1
0.1944
p.V63I
DO23452
LINC
ICGC
MALFEE
LIG_APCC_ABBA_1
0.1944
p.V63I
DO34344
PACA
ICGC
MALFEE
LIG_APCC_ABBA_1
0.1944
p.V63I
DO50431
PRAD
ICGC
MALFEE
LIG_APCC_ABBA_1
0.1944
p.V63I
DO38459
STAD
ICGC
MALFEE
LIG_APCC_ABBA_1
0.1944
p.G77V
DO229041
LICA
ICGC
MALFEE
LIG_APCC_ABBA_1
0.6667
p.V73M
DO45339
LUAD
ICGC
MALFEE
LIG_APCC_ABBA_1
0.7208
p.G60R
DO222702
MELA
ICGC
MALFEE
LIG_APCC_ABBA_1
0.1111
p.A69P
DO29398
OV
ICGC
MALFEE
LIG_APCC_ABBA_1
0.6392
p.G60E
DO229462
SKCA
ICGC
MALFEE
LIG_APCC_ABBA_1
0.1111
p.G74D
DO52412
UCEC
ICGC
MALFEE
LIG_APCC_ABBA_1
0.3056
p.S78N
SIDM01016
T-Lymphoblastic Leukemia
GDSC
MALFEE
LIG_APCC_ABBA_1
0.6389
p.S78N
SIDM01263
T-Lymphoblastic Leukemia
GDSC
MALFEE
LIG_APCC_ABBA_1
0.6389
p.S78N
Jurkat
haematopoietic_and_lymphoid_tissue
COSMIC
MALFEE
LIG_APCC_ABBA_1
0.6389
p.K61N
SIDM00188
Kidney Carcinoma
GDSC
MALFEE
LIG_APCC_ABBA_1
0.25
p.K61N
HA7-RCC
kidney
COSMIC
MALFEE
LIG_APCC_ABBA_1
0.25
p.E72A
SIDM01220
Glioma
GDSC
MALFEE
LIG_APCC_ABBA_1
0.659
p.E72A
LNZTA3WT4
central_nervous_system
COSMIC
MALFEE
LIG_APCC_ABBA_1
0.659
p.G60V
SIDM00273
Glioblastoma
GDSC
MALFEE
LIG_APCC_ABBA_1
0.1111
p.G60V
GI-1
central_nervous_system
COSMIC
MALFEE
LIG_APCC_ABBA_1
0.1111
p.M80T
SIDM00017
Squamous Cell Lung Carcinoma
GDSC
MALFEE
LIG_APCC_ABBA_1
0.1389
Drug responses associated with SLC12A5 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of MALFEE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H2X9
Solute carrier family 12 member 5
LIG_APCC_ABBA_1
68:73
MALFEE
APC,CDC20,FZR1
0.9945
More...
Q9Y666
Solute carrier family 12 member 7
LIG_APCC_ABBA_1
69:74
MALFEE
APC,CDC20,FZR1
0.9983
More...