DegronMD - Q9Y666(SLC12A7)

SLC12A7

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E74K	TCGA-18-3409	LUSC	TCGA	MALFEE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.7022
p.E74K	DO26444	LUSC	ICGC	MALFEE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.7022
p.M69I	TCGA-44-3918	LUAD	TCGA	MALFEE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.6507
p.M69I	DO23732	LUAD	ICGC	MALFEE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.6507
p.K67E	TCGA-CN-6992	HNSC	TCGA	MALFEE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.2778
p.K67E	DO14606	HNSC	ICGC	MALFEE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.2778
p.E59K	TCGA-DD-AADF	LIHC	TCGA	MALFEE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.0556
p.E59K	DO52232	LIHC	ICGC	MALFEE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.0556
p.A70T	TCGA-EO-A3AU	UCEC	TCGA	MALFEE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.6028
p.A70T	DO43827	UCEC	ICGC	MALFEE	LIG_APCC_ABBA_1	69:74	Mutation altering degron motif	0.6028
p.S62R	TCGA-EP-A26S	LIHC	TCGA	MALFEE	LIG_APCC_ABBA_1	69:74	Mutation blocking phosphorylation signal	0.5833
p.S62R	DO22854	LIHC	ICGC	MALFEE	LIG_APCC_ABBA_1	69:74	Mutation blocking phosphorylation signal	0.5833
p.E61Q	DO224980	BRCA	ICGC	MALFEE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.1111
p.S84L	SIDM01090	Colorectal Carcinoma	GDSC	MALFEE	LIG_APCC_ABBA_1	69:74	Mutation rewiring degron network	0.0556

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*NOTE: the Kaplan plots were collected from OncoLnc