DegronMD

Uniprot ID: Q9Y666

Source protein: Solute carrier family 12 member 7

Source gene: SLC12A7

Class: LIG_APCC_ABBA_1

Location: 69:74

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9983

ASA_SCORE: 77.6333

COIL: 0.435

CONS_SCORE: 0.3704

DSS_SCORE: 0.4634

HELIX: 0.5245

FCONS_SCORE: 1.2589

RIG_SCORE: 0.8052

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E74K	TCGA-18-3409	LUSC	TCGA	MALFEE	LIG_APCC_ABBA_1	0.7022
p.E74K	DO26444	LUSC	ICGC	MALFEE	LIG_APCC_ABBA_1	0.7022
p.M69I	TCGA-44-3918	LUAD	TCGA	MALFEE	LIG_APCC_ABBA_1	0.6507
p.M69I	DO23732	LUAD	ICGC	MALFEE	LIG_APCC_ABBA_1	0.6507
p.K67E	TCGA-CN-6992	HNSC	TCGA	MALFEE	LIG_APCC_ABBA_1	0.2778
p.K67E	DO14606	HNSC	ICGC	MALFEE	LIG_APCC_ABBA_1	0.2778
p.E59K	TCGA-DD-AADF	LIHC	TCGA	MALFEE	LIG_APCC_ABBA_1	0.0556
p.E59K	DO52232	LIHC	ICGC	MALFEE	LIG_APCC_ABBA_1	0.0556
p.A70T	TCGA-EO-A3AU	UCEC	TCGA	MALFEE	LIG_APCC_ABBA_1	0.6028
p.A70T	DO43827	UCEC	ICGC	MALFEE	LIG_APCC_ABBA_1	0.6028
p.S62R	TCGA-EP-A26S	LIHC	TCGA	MALFEE	LIG_APCC_ABBA_1	0.5833
p.S62R	DO22854	LIHC	ICGC	MALFEE	LIG_APCC_ABBA_1	0.5833
p.E61Q	DO224980	BRCA	ICGC	MALFEE	LIG_APCC_ABBA_1	0.1111
p.S84L	SIDM01090	Colorectal Carcinoma	GDSC	MALFEE	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2X9	Solute carrier family 12 member 5	LIG_APCC_ABBA_1	68:73	MALFEE	APC,CDC20,FZR1	0.9945	More...
Q9Y666	Solute carrier family 12 member 7	LIG_APCC_ABBA_1	69:74	MALFEE	APC,CDC20,FZR1	0.9983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons