DegronMD - Q9H324(ADAMTS10)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M801I	TCGA-06-5856	GBM	TCGA	ARTELPALR	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.25
p.R812C	TCGA-56-7582	LUSC	TCGA	ARTELPALR	DEG_APCC_DBOX_1	804:812	Mutation altering degron motif	0.719
p.R812C	DO222769	COCA	ICGC	ARTELPALR	DEG_APCC_DBOX_1	804:812	Mutation altering degron motif	0.719
p.R812C	DO26976	LUSC	ICGC	ARTELPALR	DEG_APCC_DBOX_1	804:812	Mutation altering degron motif	0.719
p.A817V	TCGA-AP-A1DV	UCEC	TCGA	ARTELPALR	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.1944
p.A817V	TCGA-EO-A22R	UCEC	TCGA	ARTELPALR	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.1944
p.R814C	TCGA-AX-A1C9	UCEC	TCGA	ARTELPALR	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.2778
p.R814C	DO43098	UCEC	ICGC	ARTELPALR	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.2778
p.F815L	TCGA-BS-A0UV	UCEC	TCGA	ARTELPALR	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.25
p.R814H	TCGA-HD-7753	HNSC	TCGA	ARTELPALR	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.2778
p.R814H	DO14614	HNSC	ICGC	ARTELPALR	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.2778
p.R814L	TCGA-XF-A9SW	BLCA	TCGA	ARTELPALR	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.2778
p.R814L	DO51915	BLCA	ICGC	ARTELPALR	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.2778
p.A796G	DO223485	CLLE	ICGC	ARTELPALR	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.1111
p.R821C	DO50326	ESAD	ICGC	ARTELPALR	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.0833
p.A810D	DO228974	LICA	ICGC	ARTELPALR	DEG_APCC_DBOX_1	804:812	Mutation altering degron motif	0.6682
p.L808R	SIDM00855	Other Sarcomas	GDSC	ARTELPALR	DEG_APCC_DBOX_1	804:812	Mutation altering degron motif	0.8428
p.L808R	SIDM01126	Small Cell Lung Carcinoma	GDSC	ARTELPALR	DEG_APCC_DBOX_1	804:812	Mutation altering degron motif	0.8428
p.L808R	SIDM00087	Plasma Cell Myeloma	GDSC	ARTELPALR	DEG_APCC_DBOX_1	804:812	Mutation altering degron motif	0.8428
p.L808R	SIDM00633	Breast Carcinoma	GDSC	ARTELPALR	DEG_APCC_DBOX_1	804:812	Mutation altering degron motif	0.8428
p.L808R	SIDM00654	Small Cell Lung Carcinoma	GDSC	ARTELPALR	DEG_APCC_DBOX_1	804:812	Mutation altering degron motif	0.8428
p.L808R	SIDM00694	Other Solid Cancers	GDSC	ARTELPALR	DEG_APCC_DBOX_1	804:812	Mutation altering degron motif	0.8428
p.L808R	SIDM00879	Breast Carcinoma	GDSC	ARTELPALR	DEG_APCC_DBOX_1	804:812	Mutation altering degron motif	0.8428
p.L808R	SIDM00971	Breast Carcinoma	GDSC	ARTELPALR	DEG_APCC_DBOX_1	804:812	Mutation altering degron motif	0.8428
p.L808R	SIDM01147	Gastric Carcinoma	GDSC	ARTELPALR	DEG_APCC_DBOX_1	804:812	Mutation altering degron motif	0.8428
p.L808R	SIDM01133	Other Solid Cancers	GDSC	ARTELPALR	DEG_APCC_DBOX_1	804:812	Mutation altering degron motif	0.8428
p.L808R	SIDM00068	Colorectal Carcinoma	GDSC	ARTELPALR	DEG_APCC_DBOX_1	804:812	Mutation altering degron motif	0.8428
p.L808R	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	ARTELPALR	DEG_APCC_DBOX_1	804:812	Mutation altering degron motif	0.8428
p.L808R	SIDM00863	Burkitt's Lymphoma	GDSC	ARTELPALR	DEG_APCC_DBOX_1	804:812	Mutation altering degron motif	0.8428
p.N795S	SIDM00257	Neuroblastoma	GDSC	ARTELPALR	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.0833
p.N795S	ACH-002280	Neuroblastoma	CCLE	ARTELPALR	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.0833
p.N795S	NB13	autonomic ganglia	COSMIC	ARTELPALR	DEG_APCC_DBOX_1	804:812	Mutation rewiring degron network	0.0833

Kaplan plot for ADAMTS10 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADAMTS10

UniProt ID: Q9H324

Entrez ID: 81794

Protein name: A disintegrin and metalloproteinase with thrombospondin motifs 10 (ADAM-TS 10) (ADAM-TS10) (ADAMTS-10) (EC 3.4.24.-)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ADAMTS10 in