DegronMD

Uniprot ID: Q9H324

Source protein: A disintegrin and metalloproteinase with thrombospondin motifs 10

Source gene: ADAMTS10

Class: DEG_APCC_DBOX_1

Location: 804:812

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5249

ASA_SCORE: 73.9556

COIL: 0.7113

CONS_SCORE: 0.4306

DSS_SCORE: 0.0304

HELIX: 0.0152

FCONS_SCORE: 0.9054

RIG_SCORE: 0.8835

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M801I	TCGA-06-5856	GBM	TCGA	ARTELPALR	DEG_APCC_DBOX_1	0.25
p.R812C	TCGA-56-7582	LUSC	TCGA	ARTELPALR	DEG_APCC_DBOX_1	0.719
p.R812C	DO222769	COCA	ICGC	ARTELPALR	DEG_APCC_DBOX_1	0.719
p.R812C	DO26976	LUSC	ICGC	ARTELPALR	DEG_APCC_DBOX_1	0.719
p.A817V	TCGA-AP-A1DV	UCEC	TCGA	ARTELPALR	DEG_APCC_DBOX_1	0.1944
p.A817V	TCGA-EO-A22R	UCEC	TCGA	ARTELPALR	DEG_APCC_DBOX_1	0.1944
p.R814C	TCGA-AX-A1C9	UCEC	TCGA	ARTELPALR	DEG_APCC_DBOX_1	0.2778
p.R814C	DO43098	UCEC	ICGC	ARTELPALR	DEG_APCC_DBOX_1	0.2778
p.F815L	TCGA-BS-A0UV	UCEC	TCGA	ARTELPALR	DEG_APCC_DBOX_1	0.25
p.R814H	TCGA-HD-7753	HNSC	TCGA	ARTELPALR	DEG_APCC_DBOX_1	0.2778
p.R814H	DO14614	HNSC	ICGC	ARTELPALR	DEG_APCC_DBOX_1	0.2778
p.R814L	TCGA-XF-A9SW	BLCA	TCGA	ARTELPALR	DEG_APCC_DBOX_1	0.2778
p.R814L	DO51915	BLCA	ICGC	ARTELPALR	DEG_APCC_DBOX_1	0.2778
p.A796G	DO223485	CLLE	ICGC	ARTELPALR	DEG_APCC_DBOX_1	0.1111
p.R821C	DO50326	ESAD	ICGC	ARTELPALR	DEG_APCC_DBOX_1	0.0833
p.A810D	DO228974	LICA	ICGC	ARTELPALR	DEG_APCC_DBOX_1	0.6682
p.L808R	SIDM00855	Other Sarcomas	GDSC	ARTELPALR	DEG_APCC_DBOX_1	0.8428
p.L808R	SIDM01126	Small Cell Lung Carcinoma	GDSC	ARTELPALR	DEG_APCC_DBOX_1	0.8428
p.L808R	SIDM00087	Plasma Cell Myeloma	GDSC	ARTELPALR	DEG_APCC_DBOX_1	0.8428
p.L808R	SIDM00633	Breast Carcinoma	GDSC	ARTELPALR	DEG_APCC_DBOX_1	0.8428
p.L808R	SIDM00654	Small Cell Lung Carcinoma	GDSC	ARTELPALR	DEG_APCC_DBOX_1	0.8428
p.L808R	SIDM00694	Other Solid Cancers	GDSC	ARTELPALR	DEG_APCC_DBOX_1	0.8428
p.L808R	SIDM00879	Breast Carcinoma	GDSC	ARTELPALR	DEG_APCC_DBOX_1	0.8428
p.L808R	SIDM00971	Breast Carcinoma	GDSC	ARTELPALR	DEG_APCC_DBOX_1	0.8428
p.L808R	SIDM01147	Gastric Carcinoma	GDSC	ARTELPALR	DEG_APCC_DBOX_1	0.8428
p.L808R	SIDM01133	Other Solid Cancers	GDSC	ARTELPALR	DEG_APCC_DBOX_1	0.8428
p.L808R	SIDM00068	Colorectal Carcinoma	GDSC	ARTELPALR	DEG_APCC_DBOX_1	0.8428
p.L808R	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	ARTELPALR	DEG_APCC_DBOX_1	0.8428
p.L808R	SIDM00863	Burkitt's Lymphoma	GDSC	ARTELPALR	DEG_APCC_DBOX_1	0.8428
p.N795S	SIDM00257	Neuroblastoma	GDSC	ARTELPALR	DEG_APCC_DBOX_1	0.0833
p.N795S	ACH-002280	Neuroblastoma	CCLE	ARTELPALR	DEG_APCC_DBOX_1	0.0833
p.N795S	NB13	autonomic_ganglia	COSMIC	ARTELPALR	DEG_APCC_DBOX_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARTELPALR

Degron related mutations and impact score

Drug responses associated with ADAMTS10 mutations

All proteins holding degron of ARTELPALR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H324	A disintegrin and metalloproteinase with thrombospondin motifs 10	DEG_APCC_DBOX_1	804:812	ARTELPALR	APC,CDC20,FZR1	0.5249	More...