DegronMD - Q9H3M0(KCNF1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G438C	TCGA-06-5416	GBM	TCGA	SRSDLDNLP	DEG_APCC_DBOX_1	445:453	Mutation rewiring degron network	0.1389
p.G438C	DO10880	GBM	ICGC	SRSDLDNLP	DEG_APCC_DBOX_1	445:453	Mutation rewiring degron network	0.1389
p.A457T	TCGA-12-0818	GBM	TCGA	SRSDLDNLP	DEG_APCC_DBOX_1	445:453	Mutation rewiring degron network	0.2222
p.A457T	DO12892	GBM	ICGC	SRSDLDNLP	DEG_APCC_DBOX_1	445:453	Mutation rewiring degron network	0.2222
p.P456H	TCGA-78-7537	LUAD	TCGA	SRSDLDNLP	DEG_APCC_DBOX_1	445:453	Mutation rewiring degron network	0.25
p.P456H	DO23574	LUAD	ICGC	SRSDLDNLP	DEG_APCC_DBOX_1	445:453	Mutation rewiring degron network	0.25
p.E439K	TCGA-AN-A046	BRCA	TCGA	SRSDLDNLP	DEG_APCC_DBOX_1	445:453	Mutation rewiring degron network	0.1667
p.E439K	TCGA-DC-6155	READ	TCGA	SRSDLDNLP	DEG_APCC_DBOX_1	445:453	Mutation rewiring degron network	0.1667
p.E439K	DO1285	BRCA	ICGC	SRSDLDNLP	DEG_APCC_DBOX_1	445:453	Mutation rewiring degron network	0.1667
p.E439K	DO36953	READ	ICGC	SRSDLDNLP	DEG_APCC_DBOX_1	445:453	Mutation rewiring degron network	0.1667
p.R446H	TCGA-AP-A1DK	UCEC	TCGA	SRSDLDNLP	DEG_APCC_DBOX_1	445:453	Mutation altering degron motif	0.8244
p.R446H	DO42033	UCEC	ICGC	SRSDLDNLP	DEG_APCC_DBOX_1	445:453	Mutation altering degron motif	0.8244
p.P462L	TCGA-FW-A3TU	SKCM	TCGA	SRSDLDNLP	DEG_APCC_DBOX_1	445:453	Mutation rewiring degron network	0.0833
p.P462L	DO37441	SKCM	ICGC	SRSDLDNLP	DEG_APCC_DBOX_1	445:453	Mutation rewiring degron network	0.0833
p.S445F	TCGA-GN-A266	SKCM	TCGA	SRSDLDNLP	DEG_APCC_DBOX_1	445:453	Mutation altering degron motif	0.6871
p.S445F	DO37432	SKCM	ICGC	SRSDLDNLP	DEG_APCC_DBOX_1	445:453	Mutation altering degron motif	0.6871
p.G458V	TCGA-S2-AA1A	LUAD	TCGA	SRSDLDNLP	DEG_APCC_DBOX_1	445:453	Mutation rewiring degron network	0.1944
p.G458V	DO51205	LUAD	ICGC	SRSDLDNLP	DEG_APCC_DBOX_1	445:453	Mutation rewiring degron network	0.1944
p.R446C	DO227867	COCA	ICGC	SRSDLDNLP	DEG_APCC_DBOX_1	445:453	Mutation altering degron motif	0.8301
p.A461G	SIDM00803	Kidney Carcinoma	GDSC	SRSDLDNLP	DEG_APCC_DBOX_1	445:453	Mutation rewiring degron network	0.1111
p.P454L	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	SRSDLDNLP	DEG_APCC_DBOX_1	445:453	Mutation rewiring degron network	0.3056
p.P454L	ACH-000824	Esophageal Cancer	CCLE	SRSDLDNLP	DEG_APCC_DBOX_1	445:453	Mutation rewiring degron network	0.3056
p.P454L	KYSE-510	oesophagus	COSMIC	SRSDLDNLP	DEG_APCC_DBOX_1	445:453	Mutation rewiring degron network	0.3056
p.L452P	ACH-000920	Leukemia	CCLE	SRSDLDNLP	DEG_APCC_DBOX_1	445:453	Mutation altering degron motif	0.7582
p.L452P	CML-T1	haematopoietic and lymphoid tissue	COSMIC	SRSDLDNLP	DEG_APCC_DBOX_1	445:453	Mutation altering degron motif	0.7582
p.A457V	ACH-000954	Endometrial/Uterine Cancer	CCLE	SRSDLDNLP	DEG_APCC_DBOX_1	445:453	Mutation rewiring degron network	0.2222
p.P454S	ACH-001408	Bladder Cancer	CCLE	SRSDLDNLP	DEG_APCC_DBOX_1	445:453	Mutation rewiring degron network	0.3056
p.T442N	ACH-001793	Liposarcoma	CCLE	SRSDLDNLP	DEG_APCC_DBOX_1	445:453	Mutation rewiring degron network	0.25

Kaplan plot for KCNF1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KCNF1

UniProt ID: Q9H3M0

Entrez ID: 3754

Protein name: Potassium voltage-gated channel subfamily F member 1 (Voltage-gated potassium channel subunit Kv5.1) (kH1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for KCNF1 in