DegronMD

Uniprot ID: Q9H3M0

Source protein: Potassium voltage-gated channel subfamily F member 1

Source gene: KCNF1

Class: DEG_APCC_DBOX_1

Location: 445:453

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9754

ASA_SCORE: 83.3222

COIL: 0.8414

CONS_SCORE: 0.454

DSS_SCORE: 0.7479

HELIX: 0.133

FCONS_SCORE: 1.1104

RIG_SCORE: 0.5987

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G438C	TCGA-06-5416	GBM	TCGA	SRSDLDNLP	DEG_APCC_DBOX_1	0.1389
p.G438C	DO10880	GBM	ICGC	SRSDLDNLP	DEG_APCC_DBOX_1	0.1389
p.A457T	TCGA-12-0818	GBM	TCGA	SRSDLDNLP	DEG_APCC_DBOX_1	0.2222
p.A457T	DO12892	GBM	ICGC	SRSDLDNLP	DEG_APCC_DBOX_1	0.2222
p.P456H	TCGA-78-7537	LUAD	TCGA	SRSDLDNLP	DEG_APCC_DBOX_1	0.25
p.P456H	DO23574	LUAD	ICGC	SRSDLDNLP	DEG_APCC_DBOX_1	0.25
p.E439K	TCGA-AN-A046	BRCA	TCGA	SRSDLDNLP	DEG_APCC_DBOX_1	0.1667
p.E439K	TCGA-DC-6155	READ	TCGA	SRSDLDNLP	DEG_APCC_DBOX_1	0.1667
p.E439K	DO1285	BRCA	ICGC	SRSDLDNLP	DEG_APCC_DBOX_1	0.1667
p.E439K	DO36953	READ	ICGC	SRSDLDNLP	DEG_APCC_DBOX_1	0.1667
p.R446H	TCGA-AP-A1DK	UCEC	TCGA	SRSDLDNLP	DEG_APCC_DBOX_1	0.8244
p.R446H	DO42033	UCEC	ICGC	SRSDLDNLP	DEG_APCC_DBOX_1	0.8244
p.P462L	TCGA-FW-A3TU	SKCM	TCGA	SRSDLDNLP	DEG_APCC_DBOX_1	0.0833
p.P462L	DO37441	SKCM	ICGC	SRSDLDNLP	DEG_APCC_DBOX_1	0.0833
p.S445F	TCGA-GN-A266	SKCM	TCGA	SRSDLDNLP	DEG_APCC_DBOX_1	0.6871
p.S445F	DO37432	SKCM	ICGC	SRSDLDNLP	DEG_APCC_DBOX_1	0.6871
p.G458V	TCGA-S2-AA1A	LUAD	TCGA	SRSDLDNLP	DEG_APCC_DBOX_1	0.1944
p.G458V	DO51205	LUAD	ICGC	SRSDLDNLP	DEG_APCC_DBOX_1	0.1944
p.R446C	DO227867	COCA	ICGC	SRSDLDNLP	DEG_APCC_DBOX_1	0.8301
p.A461G	SIDM00803	Kidney Carcinoma	GDSC	SRSDLDNLP	DEG_APCC_DBOX_1	0.1111
p.P454L	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	SRSDLDNLP	DEG_APCC_DBOX_1	0.3056
p.P454L	ACH-000824	Esophageal Cancer	CCLE	SRSDLDNLP	DEG_APCC_DBOX_1	0.3056
p.P454L	KYSE-510	oesophagus	COSMIC	SRSDLDNLP	DEG_APCC_DBOX_1	0.3056
p.L452P	ACH-000920	Leukemia	CCLE	SRSDLDNLP	DEG_APCC_DBOX_1	0.7582
p.L452P	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	SRSDLDNLP	DEG_APCC_DBOX_1	0.7582
p.A457V	ACH-000954	Endometrial/Uterine Cancer	CCLE	SRSDLDNLP	DEG_APCC_DBOX_1	0.2222
p.P454S	ACH-001408	Bladder Cancer	CCLE	SRSDLDNLP	DEG_APCC_DBOX_1	0.3056
p.T442N	ACH-001793	Liposarcoma	CCLE	SRSDLDNLP	DEG_APCC_DBOX_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRSDLDNLP

Degron related mutations and impact score

Drug responses associated with KCNF1 mutations

All proteins holding degron of SRSDLDNLP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H3M0	Potassium voltage-gated channel subfamily F member 1	DEG_APCC_DBOX_1	445:453	SRSDLDNLP	APC,CDC20,FZR1	0.9754	More...