DegronMD - Q9H3Y6(SRMS)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.C49F	TCGA-AF-5654	READ	TCGA	DPNTDPVPTL	DEG_COP1_1	35:44	Mutation rewiring degron network	0.1944
p.C49F	DO36647	READ	ICGC	DPNTDPVPTL	DEG_COP1_1	35:44	Mutation rewiring degron network	0.1944
p.P42L	TCGA-CV-5973	HNSC	TCGA	DPNTDPVPTL	DEG_COP1_1	35:44	Mutation altering degron motif	0.7582
p.P42L	DO15014	HNSC	ICGC	DPNTDPVPTL	DEG_COP1_1	35:44	Mutation altering degron motif	0.7582
p.P45S	TCGA-YD-A9TA	SKCM	TCGA	DPNTDPVPTL	DEG_COP1_1	35:44	Mutation rewiring degron network	0.3056
p.P45S	DO219503	SKCM	ICGC	DPNTDPVPTL	DEG_COP1_1	35:44	Mutation rewiring degron network	0.3056
p.H28N	DO229018	LICA	ICGC	DPNTDPVPTL	DEG_COP1_1	35:44	Mutation rewiring degron network	0.1389
p.H28N	DO229240	THCA	ICGC	DPNTDPVPTL	DEG_COP1_1	35:44	Mutation rewiring degron network	0.1389
p.P53S	DO229459	SKCA	ICGC	DPNTDPVPTL	DEG_COP1_1	35:44	Mutation rewiring degron network	0.0833
p.G32R	DO227681	SKCA	ICGC	DPNTDPVPTL	DEG_COP1_1	35:44	Mutation rewiring degron network	0.25
p.P42S	SIDM01307	Colorectal Carcinoma	GDSC	DPNTDPVPTL	DEG_COP1_1	35:44	Mutation altering degron motif	0.6752
p.P42S	SIDM00335	Endometrial Carcinoma	GDSC	DPNTDPVPTL	DEG_COP1_1	35:44	Mutation altering degron motif	0.6752
p.P42S	ACH-000192	Endometrial/Uterine Cancer	CCLE	DPNTDPVPTL	DEG_COP1_1	35:44	Mutation altering degron motif	0.6752
p.P42S	MFE-280	endometrium	COSMIC	DPNTDPVPTL	DEG_COP1_1	35:44	Mutation altering degron motif	0.6752
p.D39E	SIDM00512	Non-Small Cell Lung Carcinoma	GDSC	DPNTDPVPTL	DEG_COP1_1	35:44	Mutation altering degron motif	0.5647
p.D39E	ACH-000662	Lung Cancer	CCLE	DPNTDPVPTL	DEG_COP1_1	35:44	Mutation altering degron motif	0.5647

Kaplan plot for SRMS in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SRMS

UniProt ID: Q9H3Y6

Entrez ID: 6725

Protein name: Tyrosine-protein kinase Srms (EC 2.7.10.2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SRMS in