DegronMD

Uniprot ID: Q9H3Y6

Source protein: Tyrosine-protein kinase Srms

Source gene: SRMS

Class: DEG_COP1_1

Location: 35:44

E3 ligase: COP1

DEGRON score: 0.5739

ASA_SCORE: 94.29

COIL: 0.9628

CONS_SCORE: 0.3396

DSS_SCORE: 0.6238

HELIX: 0.0139

FCONS_SCORE: 0.9033

RIG_SCORE: 0.663

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C49F	TCGA-AF-5654	READ	TCGA	DPNTDPVPTL	DEG_COP1_1	0.1944
p.C49F	DO36647	READ	ICGC	DPNTDPVPTL	DEG_COP1_1	0.1944
p.P42L	TCGA-CV-5973	HNSC	TCGA	DPNTDPVPTL	DEG_COP1_1	0.7582
p.P42L	DO15014	HNSC	ICGC	DPNTDPVPTL	DEG_COP1_1	0.7582
p.P45S	TCGA-YD-A9TA	SKCM	TCGA	DPNTDPVPTL	DEG_COP1_1	0.3056
p.P45S	DO219503	SKCM	ICGC	DPNTDPVPTL	DEG_COP1_1	0.3056
p.H28N	DO229018	LICA	ICGC	DPNTDPVPTL	DEG_COP1_1	0.1389
p.H28N	DO229240	THCA	ICGC	DPNTDPVPTL	DEG_COP1_1	0.1389
p.P53S	DO229459	SKCA	ICGC	DPNTDPVPTL	DEG_COP1_1	0.0833
p.G32R	DO227681	SKCA	ICGC	DPNTDPVPTL	DEG_COP1_1	0.25
p.P42S	SIDM01307	Colorectal Carcinoma	GDSC	DPNTDPVPTL	DEG_COP1_1	0.6752
p.P42S	SIDM00335	Endometrial Carcinoma	GDSC	DPNTDPVPTL	DEG_COP1_1	0.6752
p.P42S	ACH-000192	Endometrial/Uterine Cancer	CCLE	DPNTDPVPTL	DEG_COP1_1	0.6752
p.P42S	MFE-280	endometrium	COSMIC	DPNTDPVPTL	DEG_COP1_1	0.6752
p.D39E	SIDM00512	Non-Small Cell Lung Carcinoma	GDSC	DPNTDPVPTL	DEG_COP1_1	0.5647
p.D39E	ACH-000662	Lung Cancer	CCLE	DPNTDPVPTL	DEG_COP1_1	0.5647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H3Y6	Tyrosine-protein kinase Srms	DEG_COP1_1	35:44	DPNTDPVPTL	COP1	0.5739	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons