LIME1
UniProt ID: Q9H400
Entrez ID: 54923
Protein name: Lck-interacting transmembrane adapter 1 (Lck-interacting membrane protein) (Lck-interacting molecule)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their asso...
FUNCTION: Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:14610046}.
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GO - Biological processes (BP):
adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; regulation of MAP kinase activity [GO:0043405]; regulation of NIK/NF-kappaB signaling [GO:1901222]; regulation of phosphatidylinositol 3-kinase signa...
adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; regulation of MAP kinase activity [GO:0043405]; regulation of NIK/NF-kappaB signaling [GO:1901222]; regulation of phosphatidylinositol 3-kinase signaling [GO:0014066]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of transcription by RNA polymerase II [GO:0006357]; T cell receptor signaling pathway [GO:0050852]
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GO - Molecular function (MF):
protein kinase binding [GO:0019901]...
protein kinase binding [GO:0019901]
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GO - Cellular component (CC):
B cell receptor complex [GO:0019815]; extracellular space [GO:0005615]; integral component of membrane [GO:0016021]...
B cell receptor complex [GO:0019815]; extracellular space [GO:0005615]; integral component of membrane [GO:0016021]
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LIME1
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*NOTE: the Kaplan plots were collected from OncoLnc