DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
RRTHLCSLS
Uniprot ID:
Q9H400
Source protein:
Lck-interacting transmembrane adapter 1
Source gene:
LIME1
Class:
DEG_APCC_DBOX_1
Location:
64:72
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9961
ASA_SCORE:
79.8667
COIL:
0.6823
CONS_SCORE:
0.8421
DSS_SCORE:
0.4143
HELIX:
0.2534
FCONS_SCORE:
0.9989
RIG_SCORE:
0.7338
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E59K
DO227535
BRCA
ICGC
RRTHLCSLS
DEG_APCC_DBOX_1
0.1944
p.L81P
ACH-000956
Prostate Cancer
CCLE
RRTHLCSLS
DEG_APCC_DBOX_1
0.0833
Drug responses associated with LIME1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RRTHLCSLS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H400
Lck-interacting transmembrane adapter 1
DEG_APCC_DBOX_1
64:72
RRTHLCSLS
APC,CDC20,FZR1
0.9961
More...