DegronMD - Q9H446(RWDD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S22F	TCGA-ER-A19B	SKCM	TCGA	QRNELEALE	DEG_APCC_DBOX_1	8:16	Mutation rewiring degron network	0.1667
p.S22F	DO47491	SKCM	ICGC	QRNELEALE	DEG_APCC_DBOX_1	8:16	Mutation rewiring degron network	0.1667
p.E6K	TCGA-G2-A2EO	BLCA	TCGA	QRNELEALE	DEG_APCC_DBOX_1	8:16	Mutation rewiring degron network	0.2778
p.E6K	DO456	BLCA	ICGC	QRNELEALE	DEG_APCC_DBOX_1	8:16	Mutation rewiring degron network	0.2778
p.Q12P	DO1101	BRCA	ICGC	QRNELEALE	DEG_APCC_DBOX_1	8:16	Mutation altering degron motif	0.7035
p.E17K	DO233726	GACA	ICGC	QRNELEALE	DEG_APCC_DBOX_1	8:16	Mutation rewiring degron network	0.3056
p.T2R	DO228815	LICA	ICGC	QRNELEALE	DEG_APCC_DBOX_1	8:16	Mutation rewiring degron network	0.1667
p.T24N	DO229232	THCA	ICGC	QRNELEALE	DEG_APCC_DBOX_1	8:16	Mutation rewiring degron network	0.1111
p.L15V	DO43154	UCEC	ICGC	QRNELEALE	DEG_APCC_DBOX_1	8:16	Mutation altering degron motif	0.5654
p.Y19S	ACH-000432	Leukemia	CCLE	QRNELEALE	DEG_APCC_DBOX_1	8:16	Mutation rewiring degron network	0.25
p.Y19S	ACH-000504	Brain Cancer	CCLE	QRNELEALE	DEG_APCC_DBOX_1	8:16	Mutation rewiring degron network	0.25
p.Y19S	ACH-000528	Lung Cancer	CCLE	QRNELEALE	DEG_APCC_DBOX_1	8:16	Mutation rewiring degron network	0.25
p.Y19S	ACH-000610	Lung Cancer	CCLE	QRNELEALE	DEG_APCC_DBOX_1	8:16	Mutation rewiring degron network	0.25
p.Y19S	ACH-000626	Myeloma	CCLE	QRNELEALE	DEG_APCC_DBOX_1	8:16	Mutation rewiring degron network	0.25
p.Q12R	TK	haematopoietic and lymphoid tissue	COSMIC	QRNELEALE	DEG_APCC_DBOX_1	8:16	Mutation altering degron motif	0.7329

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons