DegronMD

Uniprot ID: Q9H446

Source protein: RWD domain-containing protein 1

Source gene: RWDD1

Class: DEG_APCC_DBOX_1

Location: 8:16

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.65

ASA_SCORE: 55.2778

COIL: 0.024

CONS_SCORE: 0.6244

DSS_SCORE: 0.555

HELIX: 0.976

FCONS_SCORE: 1.1831

RIG_SCORE: 0.7762

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S22F	TCGA-ER-A19B	SKCM	TCGA	QRNELEALE	DEG_APCC_DBOX_1	0.1667
p.S22F	DO47491	SKCM	ICGC	QRNELEALE	DEG_APCC_DBOX_1	0.1667
p.E6K	TCGA-G2-A2EO	BLCA	TCGA	QRNELEALE	DEG_APCC_DBOX_1	0.2778
p.E6K	DO456	BLCA	ICGC	QRNELEALE	DEG_APCC_DBOX_1	0.2778
p.Q12P	DO1101	BRCA	ICGC	QRNELEALE	DEG_APCC_DBOX_1	0.7035
p.E17K	DO233726	GACA	ICGC	QRNELEALE	DEG_APCC_DBOX_1	0.3056
p.T2R	DO228815	LICA	ICGC	QRNELEALE	DEG_APCC_DBOX_1	0.1667
p.T24N	DO229232	THCA	ICGC	QRNELEALE	DEG_APCC_DBOX_1	0.1111
p.L15V	DO43154	UCEC	ICGC	QRNELEALE	DEG_APCC_DBOX_1	0.5654
p.Y19S	ACH-000432	Leukemia	CCLE	QRNELEALE	DEG_APCC_DBOX_1	0.25
p.Y19S	ACH-000504	Brain Cancer	CCLE	QRNELEALE	DEG_APCC_DBOX_1	0.25
p.Y19S	ACH-000528	Lung Cancer	CCLE	QRNELEALE	DEG_APCC_DBOX_1	0.25
p.Y19S	ACH-000610	Lung Cancer	CCLE	QRNELEALE	DEG_APCC_DBOX_1	0.25
p.Y19S	ACH-000626	Myeloma	CCLE	QRNELEALE	DEG_APCC_DBOX_1	0.25
p.Q12R	TK	haematopoietic_and_lymphoid_tissue	COSMIC	QRNELEALE	DEG_APCC_DBOX_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H446	RWD domain-containing protein 1	DEG_APCC_DBOX_1	8:16	QRNELEALE	APC,CDC20,FZR1	0.65	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons