DegronMD - Q9H4B8(DPEP3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A61T	TCGA-4Z-AA87	BLCA	TCGA	LTTPGLT	DEG_SCF_FBW7_1	64:70	Mutation rewiring degron network	0.25
p.A61T	DO218990	BLCA	ICGC	LTTPGLT	DEG_SCF_FBW7_1	64:70	Mutation rewiring degron network	0.25
p.P65Q	TCGA-A5-A1OF	UCEC	TCGA	LTTPGLT	DEG_SCF_FBW7_1	64:70	Mutation altering degron motif	0.7035
p.P65Q	DO42568	UCEC	ICGC	LTTPGLT	DEG_SCF_FBW7_1	64:70	Mutation altering degron motif	0.7035
p.P65L	TCGA-AJ-A3OJ	UCEC	TCGA	LTTPGLT	DEG_SCF_FBW7_1	64:70	Mutation altering degron motif	0.7582
p.P65L	DO42753	UCEC	ICGC	LTTPGLT	DEG_SCF_FBW7_1	64:70	Mutation altering degron motif	0.7582
p.T73M	TCGA-CK-6746	COAD	TCGA	LTTPGLT	DEG_SCF_FBW7_1	64:70	Mutation rewiring degron network	0.25
p.T73M	DO7938	COAD	ICGC	LTTPGLT	DEG_SCF_FBW7_1	64:70	Mutation rewiring degron network	0.25
p.T59I	TCGA-EO-A22U	UCEC	TCGA	LTTPGLT	DEG_SCF_FBW7_1	64:70	Mutation rewiring degron network	0.1944
p.T59I	DO43755	UCEC	ICGC	LTTPGLT	DEG_SCF_FBW7_1	64:70	Mutation rewiring degron network	0.1944
p.R60H	TCGA-F7-A623	HNSC	TCGA	LTTPGLT	DEG_SCF_FBW7_1	64:70	Mutation rewiring degron network	0.2222
p.R60H	DO44443	HNSC	ICGC	LTTPGLT	DEG_SCF_FBW7_1	64:70	Mutation rewiring degron network	0.2222
p.F80L	TCGA-G4-6628	COAD	TCGA	LTTPGLT	DEG_SCF_FBW7_1	64:70	Mutation rewiring degron network	0.0556
p.F80L	DO10132	COAD	ICGC	LTTPGLT	DEG_SCF_FBW7_1	64:70	Mutation rewiring degron network	0.0556
p.P77T	TCGA-MP-A4TF	LUAD	TCGA	LTTPGLT	DEG_SCF_FBW7_1	64:70	Mutation rewiring degron network	0.1389
p.P77T	DO45316	LUAD	ICGC	LTTPGLT	DEG_SCF_FBW7_1	64:70	Mutation rewiring degron network	0.1389
p.R60C	DO50346	ESAD	ICGC	LTTPGLT	DEG_SCF_FBW7_1	64:70	Mutation rewiring degron network	0.2222
p.R60C	SIDM01965	Esophageal Carcinoma	GDSC	LTTPGLT	DEG_SCF_FBW7_1	64:70	Mutation rewiring degron network	0.2222
p.R60S	DO223066	ESCA	ICGC	LTTPGLT	DEG_SCF_FBW7_1	64:70	Mutation rewiring degron network	0.2222
p.L79I	DO229028	LICA	ICGC	LTTPGLT	DEG_SCF_FBW7_1	64:70	Mutation rewiring degron network	0.0833
p.E62K	DO50970	LICA	ICGC	LTTPGLT	DEG_SCF_FBW7_1	64:70	Mutation rewiring degron network	0.2778
p.R55W	DO23196	LINC	ICGC	LTTPGLT	DEG_SCF_FBW7_1	64:70	Mutation rewiring degron network	0.0833
p.T64M	DO23332	LINC	ICGC	LTTPGLT	DEG_SCF_FBW7_1	64:70	Mutation altering degron motif	0.7423
p.T64M	SIDM00449	B-Lymphoblastic Leukemia	GDSC	LTTPGLT	DEG_SCF_FBW7_1	64:70	Mutation altering degron motif	0.7423
p.A67T	SIDM00282	Colorectal Carcinoma	GDSC	LTTPGLT	DEG_SCF_FBW7_1	64:70	Mutation altering degron motif	0.7139
p.A67T	ACH-000998	Colon/Colorectal Cancer	CCLE	LTTPGLT	DEG_SCF_FBW7_1	64:70	Mutation altering degron motif	0.7139

Kaplan plot for DPEP3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DPEP3

UniProt ID: Q9H4B8

Entrez ID: 64180

Protein name: Dipeptidase 3 (EC 3.4.13.19)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DPEP3 in