DegronMD

Uniprot ID: Q9H4B8

Source protein: Dipeptidase 3

Source gene: DPEP3

Class: DEG_SCF_FBW7_1

Location: 64:70

E3 ligase: FBXW7

DEGRON score: 0.9873

ASA_SCORE: 63.4

COIL: 0.8709

CONS_SCORE: 0.2815

DSS_SCORE: 0.6336

HELIX: 0.0673

FCONS_SCORE: 1.0317

RIG_SCORE: 0.666

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A61T	TCGA-4Z-AA87	BLCA	TCGA	LTTPGLT	DEG_SCF_FBW7_1	0.25
p.A61T	DO218990	BLCA	ICGC	LTTPGLT	DEG_SCF_FBW7_1	0.25
p.P65Q	TCGA-A5-A1OF	UCEC	TCGA	LTTPGLT	DEG_SCF_FBW7_1	0.7035
p.P65Q	DO42568	UCEC	ICGC	LTTPGLT	DEG_SCF_FBW7_1	0.7035
p.P65L	TCGA-AJ-A3OJ	UCEC	TCGA	LTTPGLT	DEG_SCF_FBW7_1	0.7582
p.P65L	DO42753	UCEC	ICGC	LTTPGLT	DEG_SCF_FBW7_1	0.7582
p.T73M	TCGA-CK-6746	COAD	TCGA	LTTPGLT	DEG_SCF_FBW7_1	0.25
p.T73M	DO7938	COAD	ICGC	LTTPGLT	DEG_SCF_FBW7_1	0.25
p.T59I	TCGA-EO-A22U	UCEC	TCGA	LTTPGLT	DEG_SCF_FBW7_1	0.1944
p.T59I	DO43755	UCEC	ICGC	LTTPGLT	DEG_SCF_FBW7_1	0.1944
p.R60H	TCGA-F7-A623	HNSC	TCGA	LTTPGLT	DEG_SCF_FBW7_1	0.2222
p.R60H	DO44443	HNSC	ICGC	LTTPGLT	DEG_SCF_FBW7_1	0.2222
p.F80L	TCGA-G4-6628	COAD	TCGA	LTTPGLT	DEG_SCF_FBW7_1	0.0556
p.F80L	DO10132	COAD	ICGC	LTTPGLT	DEG_SCF_FBW7_1	0.0556
p.P77T	TCGA-MP-A4TF	LUAD	TCGA	LTTPGLT	DEG_SCF_FBW7_1	0.1389
p.P77T	DO45316	LUAD	ICGC	LTTPGLT	DEG_SCF_FBW7_1	0.1389
p.R60C	DO50346	ESAD	ICGC	LTTPGLT	DEG_SCF_FBW7_1	0.2222
p.R60C	SIDM01965	Esophageal Carcinoma	GDSC	LTTPGLT	DEG_SCF_FBW7_1	0.2222
p.R60S	DO223066	ESCA	ICGC	LTTPGLT	DEG_SCF_FBW7_1	0.2222
p.L79I	DO229028	LICA	ICGC	LTTPGLT	DEG_SCF_FBW7_1	0.0833
p.E62K	DO50970	LICA	ICGC	LTTPGLT	DEG_SCF_FBW7_1	0.2778
p.R55W	DO23196	LINC	ICGC	LTTPGLT	DEG_SCF_FBW7_1	0.0833
p.T64M	DO23332	LINC	ICGC	LTTPGLT	DEG_SCF_FBW7_1	0.7423
p.T64M	SIDM00449	B-Lymphoblastic Leukemia	GDSC	LTTPGLT	DEG_SCF_FBW7_1	0.7423
p.A67T	SIDM00282	Colorectal Carcinoma	GDSC	LTTPGLT	DEG_SCF_FBW7_1	0.7139
p.A67T	ACH-000998	Colon/Colorectal Cancer	CCLE	LTTPGLT	DEG_SCF_FBW7_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4B8	Dipeptidase 3	DEG_SCF_FBW7_1	64:70	LTTPGLT	FBXW7	0.9873	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons