DegronMD - Q9H4D0(CLSTN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A647D	TCGA-AA-A010	COAD	TCGA	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation rewiring degron network	0.0833
p.V665A	TCGA-B5-A11E	UCEC	TCGA	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation rewiring degron network	0.2222
p.V665A	DO41644	UCEC	ICGC	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation rewiring degron network	0.2222
p.T657I	TCGA-B5-A11I	UCEC	TCGA	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation altering degron motif	0.5966
p.T657I	DO41229	UCEC	ICGC	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation altering degron motif	0.5966
p.E651Q	TCGA-CR-6481	HNSC	TCGA	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation rewiring degron network	0.1944
p.E651Q	DO48242	ESCA	ICGC	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation rewiring degron network	0.1944
p.E651Q	DO14990	HNSC	ICGC	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation rewiring degron network	0.1944
p.G655R	TCGA-EE-A29B	SKCM	TCGA	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation rewiring degron network	0.3056
p.G655R	DO47255	SKCM	ICGC	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation rewiring degron network	0.3056
p.T671I	TCGA-EE-A29D	SKCM	TCGA	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation blocking phosphorylation signal	0.5
p.T671I	DO38123	SKCM	ICGC	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation blocking phosphorylation signal	0.5
p.A669T	TCGA-EJ-7315	PRAD	TCGA	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation rewiring degron network	0.1111
p.A669T	TCGA-YH-A8SY	PAAD	TCGA	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation rewiring degron network	0.1111
p.A669T	DO218974	PAAD	ICGC	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation rewiring degron network	0.1111
p.A669T	DO33920	PACA	ICGC	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation rewiring degron network	0.1111
p.A669T	DO230531	PRAD	ICGC	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation rewiring degron network	0.1111
p.A669T	DO36259	PRAD	ICGC	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation rewiring degron network	0.1111
p.A669T	SIDM01041	Esophageal Carcinoma	GDSC	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation rewiring degron network	0.1111
p.A669T	ACH-001500	Esophageal Cancer	CCLE	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation rewiring degron network	0.1111
p.A669T	FLO-1	oesophagus	COSMIC	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation rewiring degron network	0.1111
p.V665L	TCGA-G4-6302	COAD	TCGA	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation rewiring degron network	0.2222
p.V665L	DO8778	COAD	ICGC	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation rewiring degron network	0.2222
p.F668V	TCGA-JX-A3Q0	CESC	TCGA	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation rewiring degron network	0.1389
p.F668V	DO51607	CESC	ICGC	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation rewiring degron network	0.1389
p.L658P	TCGA-OR-A5K2	ACC	TCGA	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation altering degron motif	0.6471
p.T671P	TCGA-V5-A7RE	ESCA	TCGA	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation blocking phosphorylation signal	0.5
p.K663T	TCGA-VR-A8EQ	ESCA	TCGA	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation rewiring degron network	0.2778
p.V665G	DO50398	ESAD	ICGC	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation rewiring degron network	0.2222
p.F659V	DO10842	ESAD	ICGC	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation altering degron motif	0.7068
p.I662M	DO44696	LICA	ICGC	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation rewiring degron network	0.3056
p.A669V	DO222696	MELA	ICGC	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation rewiring degron network	0.1111
p.T667P	DO222749	MELA	ICGC	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation blocking phosphorylation signal	0.6111
p.I664V	SIDM00602	Gastric Carcinoma	GDSC	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation rewiring degron network	0.25
p.I664V	ACH-000919	Gastric Cancer	CCLE	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation rewiring degron network	0.25
p.I664V	IM-95	stomach	COSMIC	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation rewiring degron network	0.25
p.P660T	SIDM00140	Melanoma	GDSC	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation altering degron motif	0.5919
p.P660T	ACH-000968	Skin Cancer	CCLE	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation altering degron motif	0.5919
p.P660T	COLO-792	skin	COSMIC	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation altering degron motif	0.5919
p.S666I	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation blocking phosphorylation signal	0.6389
p.S666I	ACH-000925	Lung Cancer	CCLE	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation blocking phosphorylation signal	0.6389
p.F668L	ACH-001192	Bone Cancer	CCLE	VTLFPD	LIG_APCC_ABBA_1	656:661	Mutation rewiring degron network	0.1389

Kaplan plot for CLSTN2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CLSTN2

UniProt ID: Q9H4D0

Entrez ID: 64084

Protein name: Calsyntenin-2 (Alcadein-gamma) (Alc-gamma)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CLSTN2 in