DegronMD

Uniprot ID: Q9H4D0

Source protein: Calsyntenin-2

Source gene: CLSTN2

Class: LIG_APCC_ABBA_1

Location: 656:661

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.946

ASA_SCORE: 53.0167

COIL: 0.7523

CONS_SCORE: 0.5514

DSS_SCORE: 0.189

HELIX: 0.0197

FCONS_SCORE: 1.4062

RIG_SCORE: 0.8412

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A647D	TCGA-AA-A010	COAD	TCGA	VTLFPD	LIG_APCC_ABBA_1	0.0833
p.V665A	TCGA-B5-A11E	UCEC	TCGA	VTLFPD	LIG_APCC_ABBA_1	0.2222
p.V665A	DO41644	UCEC	ICGC	VTLFPD	LIG_APCC_ABBA_1	0.2222
p.T657I	TCGA-B5-A11I	UCEC	TCGA	VTLFPD	LIG_APCC_ABBA_1	0.5966
p.T657I	DO41229	UCEC	ICGC	VTLFPD	LIG_APCC_ABBA_1	0.5966
p.E651Q	TCGA-CR-6481	HNSC	TCGA	VTLFPD	LIG_APCC_ABBA_1	0.1944
p.E651Q	DO48242	ESCA	ICGC	VTLFPD	LIG_APCC_ABBA_1	0.1944
p.E651Q	DO14990	HNSC	ICGC	VTLFPD	LIG_APCC_ABBA_1	0.1944
p.G655R	TCGA-EE-A29B	SKCM	TCGA	VTLFPD	LIG_APCC_ABBA_1	0.3056
p.G655R	DO47255	SKCM	ICGC	VTLFPD	LIG_APCC_ABBA_1	0.3056
p.T671I	TCGA-EE-A29D	SKCM	TCGA	VTLFPD	LIG_APCC_ABBA_1	0.5
p.T671I	DO38123	SKCM	ICGC	VTLFPD	LIG_APCC_ABBA_1	0.5
p.A669T	TCGA-EJ-7315	PRAD	TCGA	VTLFPD	LIG_APCC_ABBA_1	0.1111
p.A669T	TCGA-YH-A8SY	PAAD	TCGA	VTLFPD	LIG_APCC_ABBA_1	0.1111
p.A669T	DO218974	PAAD	ICGC	VTLFPD	LIG_APCC_ABBA_1	0.1111
p.A669T	DO33920	PACA	ICGC	VTLFPD	LIG_APCC_ABBA_1	0.1111
p.A669T	DO230531	PRAD	ICGC	VTLFPD	LIG_APCC_ABBA_1	0.1111
p.A669T	DO36259	PRAD	ICGC	VTLFPD	LIG_APCC_ABBA_1	0.1111
p.A669T	SIDM01041	Esophageal Carcinoma	GDSC	VTLFPD	LIG_APCC_ABBA_1	0.1111
p.A669T	ACH-001500	Esophageal Cancer	CCLE	VTLFPD	LIG_APCC_ABBA_1	0.1111
p.A669T	FLO-1	oesophagus	COSMIC	VTLFPD	LIG_APCC_ABBA_1	0.1111
p.V665L	TCGA-G4-6302	COAD	TCGA	VTLFPD	LIG_APCC_ABBA_1	0.2222
p.V665L	DO8778	COAD	ICGC	VTLFPD	LIG_APCC_ABBA_1	0.2222
p.F668V	TCGA-JX-A3Q0	CESC	TCGA	VTLFPD	LIG_APCC_ABBA_1	0.1389
p.F668V	DO51607	CESC	ICGC	VTLFPD	LIG_APCC_ABBA_1	0.1389
p.L658P	TCGA-OR-A5K2	ACC	TCGA	VTLFPD	LIG_APCC_ABBA_1	0.6471
p.T671P	TCGA-V5-A7RE	ESCA	TCGA	VTLFPD	LIG_APCC_ABBA_1	0.5
p.K663T	TCGA-VR-A8EQ	ESCA	TCGA	VTLFPD	LIG_APCC_ABBA_1	0.2778
p.V665G	DO50398	ESAD	ICGC	VTLFPD	LIG_APCC_ABBA_1	0.2222
p.F659V	DO10842	ESAD	ICGC	VTLFPD	LIG_APCC_ABBA_1	0.7068
p.I662M	DO44696	LICA	ICGC	VTLFPD	LIG_APCC_ABBA_1	0.3056
p.A669V	DO222696	MELA	ICGC	VTLFPD	LIG_APCC_ABBA_1	0.1111
p.T667P	DO222749	MELA	ICGC	VTLFPD	LIG_APCC_ABBA_1	0.6111
p.I664V	SIDM00602	Gastric Carcinoma	GDSC	VTLFPD	LIG_APCC_ABBA_1	0.25
p.I664V	ACH-000919	Gastric Cancer	CCLE	VTLFPD	LIG_APCC_ABBA_1	0.25
p.I664V	IM-95	stomach	COSMIC	VTLFPD	LIG_APCC_ABBA_1	0.25
p.P660T	SIDM00140	Melanoma	GDSC	VTLFPD	LIG_APCC_ABBA_1	0.5919
p.P660T	ACH-000968	Skin Cancer	CCLE	VTLFPD	LIG_APCC_ABBA_1	0.5919
p.P660T	COLO-792	skin	COSMIC	VTLFPD	LIG_APCC_ABBA_1	0.5919
p.S666I	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	VTLFPD	LIG_APCC_ABBA_1	0.6389
p.S666I	ACH-000925	Lung Cancer	CCLE	VTLFPD	LIG_APCC_ABBA_1	0.6389
p.F668L	ACH-001192	Bone Cancer	CCLE	VTLFPD	LIG_APCC_ABBA_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTLFPD

Degron related mutations and impact score

Drug responses associated with CLSTN2 mutations

All proteins holding degron of VTLFPD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4D0	Calsyntenin-2	LIG_APCC_ABBA_1	656:661	VTLFPD	APC,CDC20,FZR1	0.946	More...