DegronMD - Q9H4M7(PLEKHA4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G205C	TCGA-05-4396	LUAD	TCGA	LLTPSPT	DEG_SCF_FBW7_1	209:215	Mutation rewiring degron network	0.2222
p.G205C	DO23838	LUAD	ICGC	LLTPSPT	DEG_SCF_FBW7_1	209:215	Mutation rewiring degron network	0.2222
p.R225W	TCGA-2J-AAB6	PAAD	TCGA	LLTPSPT	DEG_SCF_FBW7_1	209:215	Mutation rewiring degron network	0.0556
p.R225W	TCGA-IB-7651	PAAD	TCGA	LLTPSPT	DEG_SCF_FBW7_1	209:215	Mutation rewiring degron network	0.0556
p.R225W	DO51656	PAAD	ICGC	LLTPSPT	DEG_SCF_FBW7_1	209:215	Mutation rewiring degron network	0.0556
p.R225W	DO46657	PAAD	ICGC	LLTPSPT	DEG_SCF_FBW7_1	209:215	Mutation rewiring degron network	0.0556
p.R199Q	TCGA-AX-A2HD	UCEC	TCGA	LLTPSPT	DEG_SCF_FBW7_1	209:215	Mutation rewiring degron network	0.0556
p.R199Q	DO42608	UCEC	ICGC	LLTPSPT	DEG_SCF_FBW7_1	209:215	Mutation rewiring degron network	0.0556
p.S220C	TCGA-BT-A0YX	BLCA	TCGA	LLTPSPT	DEG_SCF_FBW7_1	209:215	Mutation rewiring degron network	0.1944
p.S220C	DO516	BLCA	ICGC	LLTPSPT	DEG_SCF_FBW7_1	209:215	Mutation rewiring degron network	0.1944
p.P212S	TCGA-D3-A3CE	SKCM	TCGA	LLTPSPT	DEG_SCF_FBW7_1	209:215	Mutation altering degron motif	0.6752
p.P212S	DO37405	SKCM	ICGC	LLTPSPT	DEG_SCF_FBW7_1	209:215	Mutation altering degron motif	0.6752
p.R204C	TCGA-DF-A2KU	UCEC	TCGA	LLTPSPT	DEG_SCF_FBW7_1	209:215	Mutation rewiring degron network	0.1944
p.R204C	TCGA-EE-A29L	SKCM	TCGA	LLTPSPT	DEG_SCF_FBW7_1	209:215	Mutation rewiring degron network	0.1944
p.R204C	DO222599	MELA	ICGC	LLTPSPT	DEG_SCF_FBW7_1	209:215	Mutation rewiring degron network	0.1944
p.R204C	DO37835	SKCM	ICGC	LLTPSPT	DEG_SCF_FBW7_1	209:215	Mutation rewiring degron network	0.1944
p.R204C	DO223286	UCEC	ICGC	LLTPSPT	DEG_SCF_FBW7_1	209:215	Mutation rewiring degron network	0.1944
p.S220F	TCGA-EE-A29E	SKCM	TCGA	LLTPSPT	DEG_SCF_FBW7_1	209:215	Mutation rewiring degron network	0.1944
p.S220F	DO37831	SKCM	ICGC	LLTPSPT	DEG_SCF_FBW7_1	209:215	Mutation rewiring degron network	0.1944
p.R225L	TCGA-EE-A29Q	SKCM	TCGA	LLTPSPT	DEG_SCF_FBW7_1	209:215	Mutation rewiring degron network	0.0556
p.R225L	DO37866	SKCM	ICGC	LLTPSPT	DEG_SCF_FBW7_1	209:215	Mutation rewiring degron network	0.0556
p.R204H	DO232037	ORCA	ICGC	LLTPSPT	DEG_SCF_FBW7_1	209:215	Mutation rewiring degron network	0.1944
p.T216A	SIDM01148	Plasma Cell Myeloma	GDSC	LLTPSPT	DEG_SCF_FBW7_1	209:215	Mutation rewiring degron network	0.3056
p.T216A	SIDM00982	Glioblastoma	GDSC	LLTPSPT	DEG_SCF_FBW7_1	209:215	Mutation rewiring degron network	0.3056

Kaplan plot for PLEKHA4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLEKHA4

UniProt ID: Q9H4M7

Entrez ID: 57664

Protein name: Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLEKHA4 in