DegronMD

Uniprot ID: Q9H4M7

Source protein: Pleckstrin homology domain-containing family A member 4

Source gene: PLEKHA4

Class: DEG_SCF_FBW7_1

Location: 209:215

E3 ligase: FBXW7

DEGRON score: 0.9859

ASA_SCORE: 85.8429

COIL: 0.911

CONS_SCORE: 0.6017

DSS_SCORE: 0.7285

HELIX: 0.033

FCONS_SCORE: 1.0221

RIG_SCORE: 0.6242

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G205C	TCGA-05-4396	LUAD	TCGA	LLTPSPT	DEG_SCF_FBW7_1	0.2222
p.G205C	DO23838	LUAD	ICGC	LLTPSPT	DEG_SCF_FBW7_1	0.2222
p.R225W	TCGA-2J-AAB6	PAAD	TCGA	LLTPSPT	DEG_SCF_FBW7_1	0.0556
p.R225W	TCGA-IB-7651	PAAD	TCGA	LLTPSPT	DEG_SCF_FBW7_1	0.0556
p.R225W	DO51656	PAAD	ICGC	LLTPSPT	DEG_SCF_FBW7_1	0.0556
p.R225W	DO46657	PAAD	ICGC	LLTPSPT	DEG_SCF_FBW7_1	0.0556
p.R199Q	TCGA-AX-A2HD	UCEC	TCGA	LLTPSPT	DEG_SCF_FBW7_1	0.0556
p.R199Q	DO42608	UCEC	ICGC	LLTPSPT	DEG_SCF_FBW7_1	0.0556
p.S220C	TCGA-BT-A0YX	BLCA	TCGA	LLTPSPT	DEG_SCF_FBW7_1	0.1944
p.S220C	DO516	BLCA	ICGC	LLTPSPT	DEG_SCF_FBW7_1	0.1944
p.P212S	TCGA-D3-A3CE	SKCM	TCGA	LLTPSPT	DEG_SCF_FBW7_1	0.6752
p.P212S	DO37405	SKCM	ICGC	LLTPSPT	DEG_SCF_FBW7_1	0.6752
p.R204C	TCGA-DF-A2KU	UCEC	TCGA	LLTPSPT	DEG_SCF_FBW7_1	0.1944
p.R204C	TCGA-EE-A29L	SKCM	TCGA	LLTPSPT	DEG_SCF_FBW7_1	0.1944
p.R204C	DO222599	MELA	ICGC	LLTPSPT	DEG_SCF_FBW7_1	0.1944
p.R204C	DO37835	SKCM	ICGC	LLTPSPT	DEG_SCF_FBW7_1	0.1944
p.R204C	DO223286	UCEC	ICGC	LLTPSPT	DEG_SCF_FBW7_1	0.1944
p.S220F	TCGA-EE-A29E	SKCM	TCGA	LLTPSPT	DEG_SCF_FBW7_1	0.1944
p.S220F	DO37831	SKCM	ICGC	LLTPSPT	DEG_SCF_FBW7_1	0.1944
p.R225L	TCGA-EE-A29Q	SKCM	TCGA	LLTPSPT	DEG_SCF_FBW7_1	0.0556
p.R225L	DO37866	SKCM	ICGC	LLTPSPT	DEG_SCF_FBW7_1	0.0556
p.R204H	DO232037	ORCA	ICGC	LLTPSPT	DEG_SCF_FBW7_1	0.1944
p.T216A	SIDM01148	Plasma Cell Myeloma	GDSC	LLTPSPT	DEG_SCF_FBW7_1	0.3056
p.T216A	SIDM00982	Glioblastoma	GDSC	LLTPSPT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4M7	Pleckstrin homology domain-containing family A member 4	DEG_SCF_FBW7_1	209:215	LLTPSPT	FBXW7	0.9859	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons