DegronMD - Q9H568(ACTL8)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G243S	TCGA-22-5473	LUSC	TCGA	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation rewiring degron network	0.3056
p.G243S	TCGA-AJ-A3BH	UCEC	TCGA	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation rewiring degron network	0.3056
p.G243S	DO26467	LUSC	ICGC	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation rewiring degron network	0.3056
p.G243S	DO41638	UCEC	ICGC	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation rewiring degron network	0.3056
p.P250H	TCGA-AJ-A3OJ	UCEC	TCGA	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.6583
p.P250H	DO42753	UCEC	ICGC	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.6583
p.E234D	TCGA-E7-A541	BLCA	TCGA	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation rewiring degron network	0.0556
p.E234D	DO44037	BLCA	ICGC	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation rewiring degron network	0.0556
p.R245H	TCGA-EO-A3KX	UCEC	TCGA	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.8244
p.R245H	DO222973	BTCA	ICGC	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.8244
p.R245H	DO219774	UCEC	ICGC	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.8244
p.Y238C	TCGA-MX-A5UG	STAD	TCGA	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation blocking phosphorylation signal	0.6111
p.Y238C	DO48514	STAD	ICGC	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation blocking phosphorylation signal	0.6111
p.P250L	TCGA-XJ-A9DX	PRAD	TCGA	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.6471
p.P250L	DO51402	PRAD	ICGC	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.6471
p.R245C	DO230541	LUSC	ICGC	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.8301
p.R245C	SIDM00570	Gastric Carcinoma	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.8301
p.R245C	SIDM00232	Kidney Carcinoma	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.8301
p.R245C	SIDM00565	Oral Cavity Carcinoma	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.8301
p.R245C	SIDM00304	Ovarian Carcinoma	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.8301
p.R245C	SIDM00602	Gastric Carcinoma	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.8301
p.R245C	SIDM00040	Gastric Carcinoma	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.8301
p.R245C	SIDM00587	Biliary Tract Carcinoma	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.8301
p.R245C	SIDM00410	Other Blood Cancers	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.8301
p.R245C	SIDM00271	Gastric Carcinoma	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.8301
p.R245C	SIDM00363	Acute Myeloid Leukemia	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.8301
p.R245C	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.8301
p.R245C	SIDM01018	Hodgkin's Lymphoma	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.8301
p.R245C	SIDM00279	Gastric Carcinoma	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.8301
p.R245C	SIDM01578	Bladder Carcinoma	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.8301
p.R245C	SIDM01575	Plasma Cell Myeloma	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.8301
p.R245C	SIDM00959	Acute Myeloid Leukemia	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.8301
p.R245C	SIDM00497	Colorectal Carcinoma	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.8301
p.M251I	DO229227	THCA	ICGC	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.6507
p.E257K	SIDM00607	Glioblastoma	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation rewiring degron network	0.1944
p.E257K	ACH-000622	Brain Cancer	CCLE	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation rewiring degron network	0.1944
p.E257K	KNS-42	central nervous system	COSMIC	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation rewiring degron network	0.1944
p.P250R	SIDM01781	Gastric Carcinoma	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.6401
p.P250R	ACH-000325	Gastric Cancer	CCLE	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.6401
p.P250R	ACH-001645	Skin Cancer	CCLE	SRVELTPMQ	DEG_APCC_DBOX_1	244:252	Mutation altering degron motif	0.6401

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ACTL8

UniProt ID: Q9H568

Entrez ID: 81569

Protein name: Actin-like protein 8 (Cancer/testis antigen 57) (CT57)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ACTL8 in