DegronMD

Uniprot ID: Q9H568

Source protein: Actin-like protein 8

Source gene: ACTL8

Class: DEG_APCC_DBOX_1

Location: 244:252

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6989

ASA_SCORE: 60.2444

COIL: 0.5072

CONS_SCORE: 0.9127

DSS_SCORE: 0.508

HELIX: 0.0294

FCONS_SCORE: 1.0111

RIG_SCORE: 0.7267

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G243S	TCGA-22-5473	LUSC	TCGA	SRVELTPMQ	DEG_APCC_DBOX_1	0.3056
p.G243S	TCGA-AJ-A3BH	UCEC	TCGA	SRVELTPMQ	DEG_APCC_DBOX_1	0.3056
p.G243S	DO26467	LUSC	ICGC	SRVELTPMQ	DEG_APCC_DBOX_1	0.3056
p.G243S	DO41638	UCEC	ICGC	SRVELTPMQ	DEG_APCC_DBOX_1	0.3056
p.P250H	TCGA-AJ-A3OJ	UCEC	TCGA	SRVELTPMQ	DEG_APCC_DBOX_1	0.6583
p.P250H	DO42753	UCEC	ICGC	SRVELTPMQ	DEG_APCC_DBOX_1	0.6583
p.E234D	TCGA-E7-A541	BLCA	TCGA	SRVELTPMQ	DEG_APCC_DBOX_1	0.0556
p.E234D	DO44037	BLCA	ICGC	SRVELTPMQ	DEG_APCC_DBOX_1	0.0556
p.R245H	TCGA-EO-A3KX	UCEC	TCGA	SRVELTPMQ	DEG_APCC_DBOX_1	0.8244
p.R245H	DO222973	BTCA	ICGC	SRVELTPMQ	DEG_APCC_DBOX_1	0.8244
p.R245H	DO219774	UCEC	ICGC	SRVELTPMQ	DEG_APCC_DBOX_1	0.8244
p.Y238C	TCGA-MX-A5UG	STAD	TCGA	SRVELTPMQ	DEG_APCC_DBOX_1	0.6111
p.Y238C	DO48514	STAD	ICGC	SRVELTPMQ	DEG_APCC_DBOX_1	0.6111
p.P250L	TCGA-XJ-A9DX	PRAD	TCGA	SRVELTPMQ	DEG_APCC_DBOX_1	0.6471
p.P250L	DO51402	PRAD	ICGC	SRVELTPMQ	DEG_APCC_DBOX_1	0.6471
p.R245C	DO230541	LUSC	ICGC	SRVELTPMQ	DEG_APCC_DBOX_1	0.8301
p.R245C	SIDM00570	Gastric Carcinoma	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	0.8301
p.R245C	SIDM00232	Kidney Carcinoma	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	0.8301
p.R245C	SIDM00565	Oral Cavity Carcinoma	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	0.8301
p.R245C	SIDM00304	Ovarian Carcinoma	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	0.8301
p.R245C	SIDM00602	Gastric Carcinoma	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	0.8301
p.R245C	SIDM00040	Gastric Carcinoma	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	0.8301
p.R245C	SIDM00587	Biliary Tract Carcinoma	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	0.8301
p.R245C	SIDM00410	Other Blood Cancers	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	0.8301
p.R245C	SIDM00271	Gastric Carcinoma	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	0.8301
p.R245C	SIDM00363	Acute Myeloid Leukemia	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	0.8301
p.R245C	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	0.8301
p.R245C	SIDM01018	Hodgkin's Lymphoma	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	0.8301
p.R245C	SIDM00279	Gastric Carcinoma	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	0.8301
p.R245C	SIDM01578	Bladder Carcinoma	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	0.8301
p.R245C	SIDM01575	Plasma Cell Myeloma	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	0.8301
p.R245C	SIDM00959	Acute Myeloid Leukemia	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	0.8301
p.R245C	SIDM00497	Colorectal Carcinoma	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	0.8301
p.M251I	DO229227	THCA	ICGC	SRVELTPMQ	DEG_APCC_DBOX_1	0.6507
p.E257K	SIDM00607	Glioblastoma	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	0.1944
p.E257K	ACH-000622	Brain Cancer	CCLE	SRVELTPMQ	DEG_APCC_DBOX_1	0.1944
p.E257K	KNS-42	central_nervous_system	COSMIC	SRVELTPMQ	DEG_APCC_DBOX_1	0.1944
p.P250R	SIDM01781	Gastric Carcinoma	GDSC	SRVELTPMQ	DEG_APCC_DBOX_1	0.6401
p.P250R	ACH-000325	Gastric Cancer	CCLE	SRVELTPMQ	DEG_APCC_DBOX_1	0.6401
p.P250R	ACH-001645	Skin Cancer	CCLE	SRVELTPMQ	DEG_APCC_DBOX_1	0.6401

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRVELTPMQ

Degron related mutations and impact score

Drug responses associated with ACTL8 mutations

All proteins holding degron of SRVELTPMQ

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H568	Actin-like protein 8	DEG_APCC_DBOX_1	244:252	SRVELTPMQ	APC,CDC20,FZR1	0.6989	More...