DegronMD - Q9H583(HEATR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E1834G	TCGA-D9-A6EC	SKCM	TCGA	PRVLLPAIK	DEG_APCC_DBOX_1	1819:1827	Mutation rewiring degron network	0.1389
p.E1834G	DO50291	SKCM	ICGC	PRVLLPAIK	DEG_APCC_DBOX_1	1819:1827	Mutation rewiring degron network	0.1389
p.R1820L	TCGA-EE-A2GK	SKCM	TCGA	PRVLLPAIK	DEG_APCC_DBOX_1	1819:1827	Mutation altering degron motif	0.8428
p.R1820L	DO37738	SKCM	ICGC	PRVLLPAIK	DEG_APCC_DBOX_1	1819:1827	Mutation altering degron motif	0.8428
p.L1809H	TCGA-QC-A7B5	SARC	TCGA	PRVLLPAIK	DEG_APCC_DBOX_1	1819:1827	Mutation rewiring degron network	0.0556
p.L1809H	DO220239	SARC	ICGC	PRVLLPAIK	DEG_APCC_DBOX_1	1819:1827	Mutation rewiring degron network	0.0556
p.L1809F	TCGA-QC-A7B5	SARC	TCGA	PRVLLPAIK	DEG_APCC_DBOX_1	1819:1827	Mutation rewiring degron network	0.0556
p.L1809F	DO220239	SARC	ICGC	PRVLLPAIK	DEG_APCC_DBOX_1	1819:1827	Mutation rewiring degron network	0.0556
p.K1811T	DO233760	GACA	ICGC	PRVLLPAIK	DEG_APCC_DBOX_1	1819:1827	Mutation blocking ubiquitination signal	0.5556
p.R1820Q	SIDM00999	Bladder Carcinoma	GDSC	PRVLLPAIK	DEG_APCC_DBOX_1	1819:1827	Mutation altering degron motif	0.7329
p.R1820Q	ACH-000973	Bladder Cancer	CCLE	PRVLLPAIK	DEG_APCC_DBOX_1	1819:1827	Mutation altering degron motif	0.7329
p.R1820Q	639-V	urinary tract	COSMIC	PRVLLPAIK	DEG_APCC_DBOX_1	1819:1827	Mutation altering degron motif	0.7329
p.K1810T	SIDM00118	Colorectal Carcinoma	GDSC	PRVLLPAIK	DEG_APCC_DBOX_1	1819:1827	Mutation substituting flanking lysine	0.1944
p.K1810T	ACH-001081	Colon/Colorectal Cancer	CCLE	PRVLLPAIK	DEG_APCC_DBOX_1	1819:1827	Mutation substituting flanking lysine	0.1944
p.K1810T	HCC2998	large intestine	COSMIC	PRVLLPAIK	DEG_APCC_DBOX_1	1819:1827	Mutation substituting flanking lysine	0.1944
p.N1836D	ACH-000057	Myeloma	CCLE	PRVLLPAIK	DEG_APCC_DBOX_1	1819:1827	Mutation rewiring degron network	0.0833
p.K1831N	ACH-001369	Ovarian Cancer	CCLE	PRVLLPAIK	DEG_APCC_DBOX_1	1819:1827	Mutation blocking ubiquitination signal	0.6667

Kaplan plot for HEATR1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HEATR1

UniProt ID: Q9H583

Entrez ID: 55127

Protein name: HEAT repeat-containing protein 1 (Protein BAP28) (U3 small nucleolar RNA-associated protein 10 homolog) [Cleaved into: HEAT repeat-containing protein 1, N-terminally processed]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HEATR1 in