DegronMD

Uniprot ID: Q9H583

Source protein: HEAT repeat-containing protein 1

Source gene: HEATR1

Class: DEG_APCC_DBOX_1

Location: 1819:1827

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5387

ASA_SCORE: 47.1667

COIL: 0.0497

CONS_SCORE: 0.3691

DSS_SCORE: 0.1832

HELIX: 0.9479

FCONS_SCORE: 1.3938

RIG_SCORE: 0.8712

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1834G	TCGA-D9-A6EC	SKCM	TCGA	PRVLLPAIK	DEG_APCC_DBOX_1	0.1389
p.E1834G	DO50291	SKCM	ICGC	PRVLLPAIK	DEG_APCC_DBOX_1	0.1389
p.R1820L	TCGA-EE-A2GK	SKCM	TCGA	PRVLLPAIK	DEG_APCC_DBOX_1	0.8428
p.R1820L	DO37738	SKCM	ICGC	PRVLLPAIK	DEG_APCC_DBOX_1	0.8428
p.L1809H	TCGA-QC-A7B5	SARC	TCGA	PRVLLPAIK	DEG_APCC_DBOX_1	0.0556
p.L1809H	DO220239	SARC	ICGC	PRVLLPAIK	DEG_APCC_DBOX_1	0.0556
p.L1809F	TCGA-QC-A7B5	SARC	TCGA	PRVLLPAIK	DEG_APCC_DBOX_1	0.0556
p.L1809F	DO220239	SARC	ICGC	PRVLLPAIK	DEG_APCC_DBOX_1	0.0556
p.K1811T	DO233760	GACA	ICGC	PRVLLPAIK	DEG_APCC_DBOX_1	0.5556
p.R1820Q	SIDM00999	Bladder Carcinoma	GDSC	PRVLLPAIK	DEG_APCC_DBOX_1	0.7329
p.R1820Q	ACH-000973	Bladder Cancer	CCLE	PRVLLPAIK	DEG_APCC_DBOX_1	0.7329
p.R1820Q	639-V	urinary_tract	COSMIC	PRVLLPAIK	DEG_APCC_DBOX_1	0.7329
p.K1810T	SIDM00118	Colorectal Carcinoma	GDSC	PRVLLPAIK	DEG_APCC_DBOX_1	0.1944
p.K1810T	ACH-001081	Colon/Colorectal Cancer	CCLE	PRVLLPAIK	DEG_APCC_DBOX_1	0.1944
p.K1810T	HCC2998	large_intestine	COSMIC	PRVLLPAIK	DEG_APCC_DBOX_1	0.1944
p.N1836D	ACH-000057	Myeloma	CCLE	PRVLLPAIK	DEG_APCC_DBOX_1	0.0833
p.K1831N	ACH-001369	Ovarian Cancer	CCLE	PRVLLPAIK	DEG_APCC_DBOX_1	0.6667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H583	HEAT repeat-containing protein 1	DEG_APCC_DBOX_1	1819:1827	PRVLLPAIK	APC,CDC20,FZR1	0.5387	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons