DegronMD - Q9H598(SLC32A1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R6C	TCGA-A6-2686	COAD	TCGA	LRSKLSNVA	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.8301
p.R6C	TCGA-FP-A4BE	STAD	TCGA	LRSKLSNVA	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.8301
p.R6C	DO7828	COAD	ICGC	LRSKLSNVA	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.8301
p.R6C	DO48016	STAD	ICGC	LRSKLSNVA	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.8301
p.R6S	TCGA-AA-3989	COAD	TCGA	LRSKLSNVA	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.7427
p.R6S	DO9666	COAD	ICGC	LRSKLSNVA	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.7427
p.A2T	TCGA-DF-A2KU	UCEC	TCGA	LRSKLSNVA	DEG_APCC_DBOX_1	5:13	Mutation blocking phosphorylation signal	0.6944
p.A2T	DO223286	UCEC	ICGC	LRSKLSNVA	DEG_APCC_DBOX_1	5:13	Mutation blocking phosphorylation signal	0.6944
p.R6H	DO234336	ESAD	ICGC	LRSKLSNVA	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.8244
p.A22S	DO228976	LICA	ICGC	LRSKLSNVA	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.0833
p.T14M	DO232052	ORCA	ICGC	LRSKLSNVA	DEG_APCC_DBOX_1	5:13	Mutation rewiring degron network	0.3056
p.K23N	DO51514	PACA	ICGC	LRSKLSNVA	DEG_APCC_DBOX_1	5:13	Mutation substituting flanking lysine	0.1667
p.L9M	SIDM00945	Colorectal Carcinoma	GDSC	LRSKLSNVA	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.711
p.L9M	ACH-000895	Colon/Colorectal Cancer	CCLE	LRSKLSNVA	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.711
p.L9M	CL-34	large intestine	COSMIC	LRSKLSNVA	DEG_APCC_DBOX_1	5:13	Mutation altering degron motif	0.711
p.A2D	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	LRSKLSNVA	DEG_APCC_DBOX_1	5:13	Mutation blocking phosphorylation signal	0.6944
p.A2D	ACH-000893	Lung Cancer	CCLE	LRSKLSNVA	DEG_APCC_DBOX_1	5:13	Mutation blocking phosphorylation signal	0.6944
p.A2D	NCI-H1651	lung	COSMIC	LRSKLSNVA	DEG_APCC_DBOX_1	5:13	Mutation blocking phosphorylation signal	0.6944

Kaplan plot for SLC32A1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC32A1

UniProt ID: Q9H598

Entrez ID: 140679

Protein name: Vesicular inhibitory amino acid transporter (GABA and glycine transporter) (Solute carrier family 32 member 1) (Vesicular GABA transporter) (hVIAAT)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLC32A1 in