DegronMD

Uniprot ID: Q9H598

Source protein: Vesicular inhibitory amino acid transporter

Source gene: SLC32A1

Class: DEG_APCC_DBOX_1

Location: 5:13

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8634

ASA_SCORE: 85.0778

COIL: 0.2949

CONS_SCORE: 0.2655

DSS_SCORE: 0.4523

HELIX: 0.687

FCONS_SCORE: 0.9952

RIG_SCORE: 0.7676

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R6C	TCGA-A6-2686	COAD	TCGA	LRSKLSNVA	DEG_APCC_DBOX_1	0.8301
p.R6C	TCGA-FP-A4BE	STAD	TCGA	LRSKLSNVA	DEG_APCC_DBOX_1	0.8301
p.R6C	DO7828	COAD	ICGC	LRSKLSNVA	DEG_APCC_DBOX_1	0.8301
p.R6C	DO48016	STAD	ICGC	LRSKLSNVA	DEG_APCC_DBOX_1	0.8301
p.R6S	TCGA-AA-3989	COAD	TCGA	LRSKLSNVA	DEG_APCC_DBOX_1	0.7427
p.R6S	DO9666	COAD	ICGC	LRSKLSNVA	DEG_APCC_DBOX_1	0.7427
p.A2T	TCGA-DF-A2KU	UCEC	TCGA	LRSKLSNVA	DEG_APCC_DBOX_1	0.6944
p.A2T	DO223286	UCEC	ICGC	LRSKLSNVA	DEG_APCC_DBOX_1	0.6944
p.R6H	DO234336	ESAD	ICGC	LRSKLSNVA	DEG_APCC_DBOX_1	0.8244
p.A22S	DO228976	LICA	ICGC	LRSKLSNVA	DEG_APCC_DBOX_1	0.0833
p.T14M	DO232052	ORCA	ICGC	LRSKLSNVA	DEG_APCC_DBOX_1	0.3056
p.K23N	DO51514	PACA	ICGC	LRSKLSNVA	DEG_APCC_DBOX_1	0.1667
p.L9M	SIDM00945	Colorectal Carcinoma	GDSC	LRSKLSNVA	DEG_APCC_DBOX_1	0.711
p.L9M	ACH-000895	Colon/Colorectal Cancer	CCLE	LRSKLSNVA	DEG_APCC_DBOX_1	0.711
p.L9M	CL-34	large_intestine	COSMIC	LRSKLSNVA	DEG_APCC_DBOX_1	0.711
p.A2D	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	LRSKLSNVA	DEG_APCC_DBOX_1	0.6944
p.A2D	ACH-000893	Lung Cancer	CCLE	LRSKLSNVA	DEG_APCC_DBOX_1	0.6944
p.A2D	NCI-H1651	lung	COSMIC	LRSKLSNVA	DEG_APCC_DBOX_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H598	Vesicular inhibitory amino acid transporter	DEG_APCC_DBOX_1	5:13	LRSKLSNVA	APC,CDC20,FZR1	0.8634	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons