DegronMD - Q9H5H4(ZNF768)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P215T	TCGA-55-8511	LUAD	TCGA	LLSTPQFE	DEG_SCF_FBW7_2	223:230	Mutation rewiring degron network	0.1111
p.P215T	DO24940	LUAD	ICGC	LLSTPQFE	DEG_SCF_FBW7_2	223:230	Mutation rewiring degron network	0.1111
p.R228W	DO51615	CESC	ICGC	LLSTPQFE	DEG_SCF_FBW7_2	223:230	Mutation altering degron motif	0.8634
p.R217W	DO222765	COCA	ICGC	LLSTPQFE	DEG_SCF_FBW7_2	223:230	Mutation rewiring degron network	0.1667
p.L232I	DO229009	LICA	ICGC	LLSTPQFE	DEG_SCF_FBW7_2	223:230	Mutation rewiring degron network	0.2778
p.R216W	DO222843	MELA	ICGC	LLSTPQFE	DEG_SCF_FBW7_2	223:230	Mutation rewiring degron network	0.1389
p.P227S	DO51276	SKCM	ICGC	LLSTPQFE	DEG_SCF_FBW7_2	223:230	Mutation altering degron motif	0.6752
p.C232Y	DO231351	THCA	ICGC	LLSTPQFE	DEG_SCF_FBW7_2	223:230	Mutation rewiring degron network	0.2778
p.F229L	SIDM01071	Small Cell Lung Carcinoma	GDSC	LLSTPQFE	DEG_SCF_FBW7_2	223:230	Mutation altering degron motif	0.587
p.F229L	HCC-33	lung	COSMIC	LLSTPQFE	DEG_SCF_FBW7_2	223:230	Mutation altering degron motif	0.587
p.P227L	SIDM00596	Endometrial Carcinoma	GDSC	LLSTPQFE	DEG_SCF_FBW7_2	223:230	Mutation altering degron motif	0.7582
p.P227L	ACH-000941	Endometrial/Uterine Cancer	CCLE	LLSTPQFE	DEG_SCF_FBW7_2	223:230	Mutation altering degron motif	0.7582
p.P227L	ACH-000954	Endometrial/Uterine Cancer	CCLE	LLSTPQFE	DEG_SCF_FBW7_2	223:230	Mutation altering degron motif	0.7582
p.P227L	ACH-001517	Endometrial/Uterine Cancer	CCLE	LLSTPQFE	DEG_SCF_FBW7_2	223:230	Mutation altering degron motif	0.7582
p.P227L	HEC-1	endometrium	COSMIC	LLSTPQFE	DEG_SCF_FBW7_2	223:230	Mutation altering degron motif	0.7582
p.M231I	SIDM00522	Small Cell Lung Carcinoma	GDSC	LLSTPQFE	DEG_SCF_FBW7_2	223:230	Mutation rewiring degron network	0.3056
p.M231I	ACH-000749	Lung Cancer	CCLE	LLSTPQFE	DEG_SCF_FBW7_2	223:230	Mutation rewiring degron network	0.3056
p.M231I	DMS-273	lung	COSMIC	LLSTPQFE	DEG_SCF_FBW7_2	223:230	Mutation rewiring degron network	0.3056
p.M218L	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	LLSTPQFE	DEG_SCF_FBW7_2	223:230	Mutation rewiring degron network	0.1944
p.M218L	ACH-000845	Lung Cancer	CCLE	LLSTPQFE	DEG_SCF_FBW7_2	223:230	Mutation rewiring degron network	0.1944
p.G236R	LS-1034	large intestine	COSMIC	LLSTPQFE	DEG_SCF_FBW7_2	223:230	Mutation rewiring degron network	0.1667
p.R217P	NCI-H146	lung	COSMIC	LLSTPQFE	DEG_SCF_FBW7_2	223:230	Mutation rewiring degron network	0.1667
p.G233R	HD-MY-Z	haematopoietic and lymphoid tissue	COSMIC	LLSTPQFE	DEG_SCF_FBW7_2	223:230	Mutation rewiring degron network	0.25

Kaplan plot for ZNF768 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF768

UniProt ID: Q9H5H4

Entrez ID: 79724

Protein name: Zinc finger protein 768

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF768 in