DegronMD

Uniprot ID: Q9H5H4

Source protein: Zinc finger protein 768

Source gene: ZNF768

Class: DEG_SCF_FBW7_2

Location: 223:230

E3 ligase: FBXW7

DEGRON score: 0.6095

ASA_SCORE: 64.4875

COIL: 0.5579

CONS_SCORE: 0.8897

DSS_SCORE: 0.5691

HELIX: 0.3203

FCONS_SCORE: 1.0241

RIG_SCORE: 0.7773

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P215T	TCGA-55-8511	LUAD	TCGA	LLSTPQFE	DEG_SCF_FBW7_2	0.1111
p.P215T	DO24940	LUAD	ICGC	LLSTPQFE	DEG_SCF_FBW7_2	0.1111
p.R228W	DO51615	CESC	ICGC	LLSTPQFE	DEG_SCF_FBW7_2	0.8634
p.R217W	DO222765	COCA	ICGC	LLSTPQFE	DEG_SCF_FBW7_2	0.1667
p.L232I	DO229009	LICA	ICGC	LLSTPQFE	DEG_SCF_FBW7_2	0.2778
p.R216W	DO222843	MELA	ICGC	LLSTPQFE	DEG_SCF_FBW7_2	0.1389
p.P227S	DO51276	SKCM	ICGC	LLSTPQFE	DEG_SCF_FBW7_2	0.6752
p.C232Y	DO231351	THCA	ICGC	LLSTPQFE	DEG_SCF_FBW7_2	0.2778
p.F229L	SIDM01071	Small Cell Lung Carcinoma	GDSC	LLSTPQFE	DEG_SCF_FBW7_2	0.587
p.F229L	HCC-33	lung	COSMIC	LLSTPQFE	DEG_SCF_FBW7_2	0.587
p.P227L	SIDM00596	Endometrial Carcinoma	GDSC	LLSTPQFE	DEG_SCF_FBW7_2	0.7582
p.P227L	ACH-000941	Endometrial/Uterine Cancer	CCLE	LLSTPQFE	DEG_SCF_FBW7_2	0.7582
p.P227L	ACH-000954	Endometrial/Uterine Cancer	CCLE	LLSTPQFE	DEG_SCF_FBW7_2	0.7582
p.P227L	ACH-001517	Endometrial/Uterine Cancer	CCLE	LLSTPQFE	DEG_SCF_FBW7_2	0.7582
p.P227L	HEC-1	endometrium	COSMIC	LLSTPQFE	DEG_SCF_FBW7_2	0.7582
p.M231I	SIDM00522	Small Cell Lung Carcinoma	GDSC	LLSTPQFE	DEG_SCF_FBW7_2	0.3056
p.M231I	ACH-000749	Lung Cancer	CCLE	LLSTPQFE	DEG_SCF_FBW7_2	0.3056
p.M231I	DMS-273	lung	COSMIC	LLSTPQFE	DEG_SCF_FBW7_2	0.3056
p.M218L	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	LLSTPQFE	DEG_SCF_FBW7_2	0.1944
p.M218L	ACH-000845	Lung Cancer	CCLE	LLSTPQFE	DEG_SCF_FBW7_2	0.1944
p.G236R	LS-1034	large_intestine	COSMIC	LLSTPQFE	DEG_SCF_FBW7_2	0.1667
p.R217P	NCI-H146	lung	COSMIC	LLSTPQFE	DEG_SCF_FBW7_2	0.1667
p.G233R	HD-MY-Z	haematopoietic_and_lymphoid_tissue	COSMIC	LLSTPQFE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H5H4	Zinc finger protein 768	DEG_SCF_FBW7_2	223:230	LLSTPQFE	FBXW7	0.6095	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons