DegronMD - Q9H5P4(PDZD7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T40K	TCGA-55-6972	LUAD	TCGA	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation altering degron motif	0.7306
p.T40K	DO25010	LUAD	ICGC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation altering degron motif	0.7306
p.R41Q	TCGA-B5-A3FC	UCEC	TCGA	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation rewiring degron network	0.3056
p.R41Q	DO229051	LICA	ICGC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation rewiring degron network	0.3056
p.R41Q	DO41871	UCEC	ICGC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation rewiring degron network	0.3056
p.R41G	TCGA-D9-A148	SKCM	TCGA	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation rewiring degron network	0.3056
p.R41G	DO37971	SKCM	ICGC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation rewiring degron network	0.3056
p.T40M	TCGA-EZ-7264	LGG	TCGA	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation altering degron motif	0.7423
p.T40M	DO22145	LGG	ICGC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation altering degron motif	0.7423
p.L31Q	TCGA-NC-A5HN	LUSC	TCGA	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation rewiring degron network	0.25
p.L31Q	DO52025	LUSC	ICGC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation rewiring degron network	0.25
p.T38N	DO229031	LICA	ICGC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation altering degron motif	0.5944
p.R28Q	DO228503	PRAD	ICGC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation rewiring degron network	0.1667
p.D34E	SIDM01043	Other Sarcomas	GDSC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation altering degron motif	0.6758
p.D34E	ACH-000913	Endometrial/Uterine Cancer	CCLE	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation altering degron motif	0.6758
p.D34E	ESS-1	endometrium	COSMIC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation altering degron motif	0.6758
p.R49Q	SIDM00353	Other Sarcomas	GDSC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation rewiring degron network	0.0833
p.R49Q	SIDM01151	Hepatocellular Carcinoma	GDSC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation rewiring degron network	0.0833
p.R49Q	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation rewiring degron network	0.0833
p.R49Q	SIDM00556	Neuroblastoma	GDSC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation rewiring degron network	0.0833
p.R49Q	SIDM01172	Acute Myeloid Leukemia	GDSC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation rewiring degron network	0.0833
p.R49Q	SIDM01019	Acute Myeloid Leukemia	GDSC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation rewiring degron network	0.0833
p.R49Q	SIDM00280	Gastric Carcinoma	GDSC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation rewiring degron network	0.0833
p.R49Q	SIDM00618	Hepatocellular Carcinoma	GDSC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation rewiring degron network	0.0833
p.R49Q	SIDM00368	Small Cell Lung Carcinoma	GDSC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation rewiring degron network	0.0833
p.R49Q	SIDM00302	Other Solid Cancers	GDSC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation rewiring degron network	0.0833
p.R49Q	SIDM01463	Endometrial Carcinoma	GDSC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation rewiring degron network	0.0833
p.R49Q	SIDM01660	Kidney Carcinoma	GDSC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation rewiring degron network	0.0833
p.R49Q	SIDM01391	Neuroblastoma	GDSC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation rewiring degron network	0.0833
p.R49Q	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation rewiring degron network	0.0833
p.R49Q	SIDM01729	Endometrial Carcinoma	GDSC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation rewiring degron network	0.0833
p.A804V	SIDM01245	T-Lymphoblastic Leukemia	GDSC	PVPTPAPS	DEG_SCF_FBW7_1	799:806	Mutation altering degron motif	0.5825
p.A804V	BE-13	haematopoietic and lymphoid tissue	COSMIC	PVPTPAPS	DEG_SCF_FBW7_1	799:806	Mutation altering degron motif	0.5825
p.P815L	SIDM00217	Colorectal Carcinoma	GDSC	PVPTPAPS	DEG_SCF_FBW7_1	799:806	Mutation rewiring degron network	0.0833
p.P815L	SNU-1040	large intestine	COSMIC	PVPTPAPS	DEG_SCF_FBW7_1	799:806	Mutation rewiring degron network	0.0833
p.G36D	SIDM01318	Hepatocellular Carcinoma	GDSC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation altering degron motif	0.7198
p.G36D	ACH-001318	Liver Cancer	CCLE	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation altering degron motif	0.7198

Kaplan plot for PDZD7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PDZD7

UniProt ID: Q9H5P4

Entrez ID: 79955

Protein name: PDZ domain-containing protein 7

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PDZD7 in