DegronMD - Q9H5P4(PDZD7)

FUNCTION: In cochlear developing hair cells, essential in organizing the USH2 complex at stereocilia ankle links. Blocks inhibition of adenylate cyclase activity mediated by ADGRV1. {ECO:0000250|UniProtKB:E9Q9W7}.

GO - Biological processes (BP): auditory receptor cell development [GO:0060117]; auditory receptor cell stereocilium organization [GO:0060088]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; establishment of protein localization [GO:0045184]; sensory perception of sound [GO:0007605]

GO - Molecular function (MF): identical protein binding [GO:0042802]

GO - Cellular component (CC): cilium [GO:0005929]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426]; USH2 complex [GO:1990696]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T40M	TCGA-EZ-7264	LGG	TCGA	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation altering degron motif	0.7423
p.T40M	DO22145	LGG	ICGC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation altering degron motif	0.7423
p.T40K	TCGA-55-6972	LUAD	TCGA	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation altering degron motif	0.7306
p.T40K	DO25010	LUAD	ICGC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation altering degron motif	0.7306
p.G36D	SIDM01318	Hepatocellular Carcinoma	GDSC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation altering degron motif	0.7198
p.G36D	ACH-001318	Liver Cancer	CCLE	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation altering degron motif	0.7198
p.D34E	SIDM01043	Other Sarcomas	GDSC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation altering degron motif	0.6758
p.D34E	ACH-000913	Endometrial/Uterine Cancer	CCLE	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation altering degron motif	0.6758
p.D34E	ESS-1	endometrium	COSMIC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation altering degron motif	0.6758
p.T38N	DO229031	LICA	ICGC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation altering degron motif	0.5944
p.A804V	SIDM01245	T-Lymphoblastic Leukemia	GDSC	PVPTPAPS	DEG_SCF_FBW7_1	799:806	Mutation altering degron motif	0.5825
p.A804V	BE-13	haematopoietic and lymphoid tissue	COSMIC	PVPTPAPS	DEG_SCF_FBW7_1	799:806	Mutation altering degron motif	0.5825
p.R41Q	TCGA-B5-A3FC	UCEC	TCGA	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation rewiring degron network	0.3056
p.R41Q	DO229051	LICA	ICGC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation rewiring degron network	0.3056
p.R41Q	DO41871	UCEC	ICGC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation rewiring degron network	0.3056
p.R41G	TCGA-D9-A148	SKCM	TCGA	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation rewiring degron network	0.3056
p.R41G	DO37971	SKCM	ICGC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation rewiring degron network	0.3056
p.L31Q	TCGA-NC-A5HN	LUSC	TCGA	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation rewiring degron network	0.25
p.L31Q	DO52025	LUSC	ICGC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation rewiring degron network	0.25
p.R28Q	DO228503	PRAD	ICGC	DSGSTAT	DEG_SCF_TRCP1_1	34:40	Mutation rewiring degron network	0.1667

Showing 1 to 20 of 37 entries

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No resistance data available for this Degron.

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

PDZD7

UniProt ID: Q9H5P4

Entrez ID: 79955

Protein name: PDZ domain-containing protein 7

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for PDZD7 in